Active, not recruitingInterventional · Not applicableNCT04722250 ↗SMall Annuli Randomized To Evolut™ or SAPIEN™ Trial
RecruitingInterventional · Not applicableNCT05172973 ↗Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic ValvesShmuel ChenPIInterventionDevice: SAPIEN X4/X4S THVDatesNov 2023 – Mar 2029 (est.)SponsorEdwards Lifesciences Corp.Aortic Valve InsufficiencyAortic Valve Stenosis
TerminatedInterventional · Not applicableNCT03618095 ↗REPRISE IV: REpositionable Percutaneous Replacement of Stenotic Aortic Valve Through Implantation of LOTUS Edge Valve System in IntermediatE Surgical Risk SubjectsGeoffrey W BergmanPIInterventionDevice: LOTUS Edge Valve SystemDatesJan 2019 – Mar 2021· Results postedSponsorBoston Scientific CorporationAortic Valve Stenosis
TerminatedInterventional · Phase 3NCT04142658 ↗A Prospective, Randomized, Active (Warfarin) Controlled, Parallel-arm Clinical Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely and Effectively on ApixabanChristopher LauPIInterventionDrug: Apixaban 5 MG · Drug: Apixaban 2.5 MG · Drug: Warfarin · Device: On-X Aortic Mechanical ValveDatesMay 2020 – Dec 2022· Results postedSponsorCryoLife, Inc.Aortic Valve DiseaseAortic Valve StenosisAortic Valve Failure