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Scholars/Taha Merghoub, PhD/Co-authored with mentees

Co-authored publications with mentees

Taha Merghoub, PhD · 19 publications across 8 mentees

MD mentee

Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.
Science translational medicine · 2022
TMTaha MerghoubJJJoseph J ParkRZRoberta Zappasodi DRDavid RedmondSVSvena Verma+8 more →
PMID: 35704596PMCID: PMC11182673DOI31 citations
With Joseph Park · MD mentee · Class of 2020
Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer.
Communications biology · 2021
TMTaha MerghoubAGAditi GuptaSBSadna BudhuAHAliya HollandJDJedd D Wolchok
PMID: 34789823PMCID: PMC8599839DOI15 citations
With Aditi Gupta · MD mentee · Class of 2019
Tim-4⁺ cavity-resident macrophages impair anti-tumor CD8⁺ T cell immunity.
Cancer cell · 2021
TMTaha MerghoubAGAditi GuptaSSSara SchadDZDmitriy ZamarinSBSadna Budhu+7 more →
PMID: 34115989PMCID: PMC9115604DOI172 citations
With Aditi Gupta · MD mentee · Class of 2019
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports · 2021
TMTaha MerghoubAGAditi GuptaSBSadna Budhu RZRoberta ZappasodiSSSara Schad+3 more →
PMID: 33440157PMCID: PMC8100747DOI49 citations
With Aditi Gupta · MD mentee · Class of 2019
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors.
The Journal of clinical investigation · 2019
TMTaha MerghoubAGAditi GuptaSBSadna Budhu DRDavid RedmondRMRobert M Samstein+5 more →
PMID: 31329159PMCID: PMC6668692DOI43 citations
With Aditi Gupta · MD mentee · Class of 2019
One checkpoint may hide another: inhibiting the TGFβ signaling pathway enhances immune checkpoint blockade.
Hepatobiliary surgery and nutrition · 2019
TMTaha MerghoubAGAditi GuptaSBSadna Budhu
PMID: 31245417PMCID: PMC6561888DOI383 citations
With Aditi Gupta · MD mentee · Class of 2019

Postdoc mentee

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.
The Journal of experimental medicine · 2026
TMTaha Merghoub JFJonathan F. KhanADAlyssa Duren-LubanskiWCWinson CaiDHDaniel Hirschhorn+7 more →
PMID: 42360231DOI1 citations
With Jonathan F. Khan · Pharmacology
Immune checkpoint blockade augments lymphodepleting chemotherapy-induced antitumor immunity by expanding effector CD8+ T cell clones.
Cancer research · 2026
TMTaha MerghoubLDLauren DongMMMariam Mathew George DHDaniel Hirschhorn ISIsabell Schulze+3 more →
PMID: 42329854DOI
With Lauren Dong · Pharmacology · Class of 2023
Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.
Cell reports · 2026
TMTaha Merghoub JFJonathan F. Khan CWChien-Huan WengCSChana SchochetVPVincent Panneton+8 more →
PMID: 42213780DOI1 citations
With Jonathan F. Khan · Pharmacology
Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.
Cell reports · 2026
TMTaha Merghoub AAAnais Assouvie CWChien-Huan WengCSChana SchochetVPVincent Panneton+8 more →
PMID: 42213780DOI1 citations
With Anais Assouvie · Postdoc mentee
Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.
Cell reports · 2026
TMTaha MerghoubVPVincent PannetonCWChien-Huan WengCSChana SchochetAAAnais Assouvie+8 more →
PMID: 42213780DOI1 citations
With Vincent Panneton · Postdoc mentee
Effective PD-1 checkpoint blockade in bladder cancer model requires tumor-draining lymph nodes and lymphocyte trafficking.
Urologic oncology · 2026
TMTaha Merghoub JFJonathan F. KhanJCJuan C Angulo-LozanoLPLina Posada-Calderon+6 more →DSDouglas S Scherr
PMID: 42167990DOI
With Jonathan F. Khan · Pharmacology
Thrombospondin-1-CD47 signaling contributes to the development of T cell exhaustion in cancer.
Nature immunology · 2025
TMTaha Merghoub JFJonathan F. Khan CWChien-Huan Weng AAAnais AssouvieLDLauren Dong+9 more →
PMID: 41249483PMCID: PMC13536922DOI14 citations
With Jonathan F. Khan · Pharmacology
Thrombospondin-1-CD47 signaling contributes to the development of T cell exhaustion in cancer.
Nature immunology · 2025
TMTaha MerghoubLDLauren DongCWChien-Huan Weng AAAnais Assouvie SBSadna Budhu+9 more →
PMID: 41249483PMCID: PMC13536922DOI14 citations
With Lauren Dong · Pharmacology · Class of 2023
Thrombospondin-1-CD47 signaling contributes to the development of T cell exhaustion in cancer.
Nature immunology · 2025
TMTaha Merghoub AAAnais Assouvie CWChien-Huan WengLDLauren DongSBSadna Budhu+9 more →
PMID: 41249483PMCID: PMC13536922DOI14 citations
With Anais Assouvie · Postdoc mentee
CHI3L3⁺ immature neutrophils inhibit anti-tumor immunity and impede immune checkpoint blockade therapy in bone metastases.
Cancer cell · 2025
TMTaha MerghoubTSTao ShiDHDaniel Hirschhorn
PMID: 40780215DOI24 citations
With Tao Shi · Postdoc mentee
Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition.
Journal of hematology & oncology · 2025
TMTaha MerghoubTSTao ShiSKSimone Krebs
PMID: 39806516PMCID: PMC11733683DOI147 citations
With Tao Shi · Postdoc mentee
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.
The Journal of clinical investigation · 2024
TMTaha Merghoub JFJonathan F. KhanSVSvena VermaSBSadna Budhu ISInna Sergeevna Serganova+5 more →
PMID: 39225102PMCID: PMC11364391DOI86 citations
With Jonathan F. Khan · Pharmacology
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.
The Journal of clinical investigation · 2024
TMTaha MerghoubSVSvena VermaSBSadna Budhu ISInna Sergeevna Serganova JFJonathan F. Khan+5 more →
PMID: 39225102PMCID: PMC11364391DOI86 citations
With Svena Verma · Pharmacology
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.
The Journal of clinical investigation · 2024
TMTaha Merghoub AAAnais AssouvieSVSvena VermaSBSadna Budhu ISInna Sergeevna Serganova+5 more →
PMID: 39225102PMCID: PMC11364391DOI86 citations
With Anais Assouvie · Postdoc mentee
Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.
Cancer immunology research · 2024
TMTaha Merghoub JFJonathan F. KhanLDLauren DongSBSadna Budhu ISIsabell Schulze+4 more →
PMID: 38885362PMCID: PMC12679059DOI7 citations
With Jonathan F. Khan · Pharmacology
Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.
Cancer immunology research · 2024
TMTaha MerghoubSVSvena VermaLDLauren DongSBSadna Budhu ISIsabell Schulze+4 more →
PMID: 38885362PMCID: PMC12679059DOI7 citations
With Svena Verma · Pharmacology
Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.
Cancer immunology research · 2024
TMTaha MerghoubLDLauren DongSBSadna Budhu ISIsabell SchulzeSVSvena Verma+4 more →
PMID: 38885362PMCID: PMC12679059DOI7 citations
With Lauren Dong · Pharmacology · Class of 2023
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.
Cancer cell · 2023
TMTaha MerghoubSVSvena VermaJDJedd D Wolchok
PMID: 37327788PMCID: PMC11161201DOI179 citations
With Svena Verma · Pharmacology
Increased p53 expression induced by APR-246 reprograms tumor-associated macrophages to augment immune checkpoint blockade.
The Journal of clinical investigation · 2022
TMTaha MerghoubLDLauren DongDVDivya VenkateshAHAliya Holland+3 more →JDJedd D Wolchok
PMID: 36106631PMCID: PMC9479603DOI27 citations
With Lauren Dong · Pharmacology · Class of 2023
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.
Science translational medicine · 2022
TMTaha MerghoubSVSvena VermaRZRoberta ZappasodiJJJoseph J ParkDRDavid Redmond+8 more →
PMID: 35704596PMCID: PMC11182673DOI31 citations
With Svena Verma · Pharmacology
CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours.
Nature · 2021
TMTaha MerghoubSVSvena VermaRZRoberta Zappasodi ISInna Sergeevna SerganovaRMRachana Maniyar+3 more →
PMID: 33588426PMCID: PMC8057670DOI356 citations
With Svena Verma · Pharmacology
Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.
Cell reports · 2019
TMTaha MerghoubLDLauren DongEJElliott J BreaDRDavid Redmond JDJedd D Wolchok
PMID: 30995478PMCID: PMC6719696DOI66 citations
With Lauren Dong · Pharmacology · Class of 2023