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Scholars/Sabine Ehrt, PhD/Co-authored with mentees

Co-authored publications with mentees

Sabine Ehrt, PhD · 23 publications across 10 mentees

PhD mentee

The WhiA and WhiB2 transcription factors mediate the Mycobacterium tuberculosis cell cycle by regulating DNA replication and cell division.
NAR molecular medicine · 2026
SESabine EhrtFMFrances Marks
PMID: 42602178PMCID: PMC13473873DOI
With Frances Marks · Molecular Biology (PhD) · Class of 2025
A periplasmic protein complex mediates arabinofuranosyltransferase activity and intrinsic drug resistance in Mycobacterium tuberculosis.
Science advances · 2026
SESabine EhrtTKThaís KlevornCDChristopher David Brown DSDirk Schnappinger KYKyu Y. Rhee
PMID: 41920993PMCID: PMC13041763DOI1 citations
With Thais Klevorn · Immunology & Microbial Pathogenesis (PhD) · Class of 2025
Engineered Mycobacterium tuberculosis triple-kill-switch strain provides controlled tuberculosis infection in animal models.
Nature microbiology · 2025
SESabine EhrtTKThais KlevornDSDirk Schnappinger
PMID: 39794471PMCID: PMC11790485DOI19 citations
With Thais Klevorn · Immunology & Microbial Pathogenesis (PhD) · Class of 2025
Interruption of mycothiol synthesis and intracellular redox status impact iron-regulated reporter activation in Mycobacterium smegmatis.
Microbiology spectrum · 2024
SESabine EhrtFMFrances MarksAHAlexandra H MillerHBHelene BotellaDSDirk Schnappinger
PMID: 38860795PMCID: PMC11218476DOI4 citations
With Frances Marks · Molecular Biology (PhD) · Class of 2025
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model.
bioRxiv : the preprint server for biology · 2023
SESabine EhrtTKThais KlevornDSDirk Schnappinger
PMID: 38014062PMCID: PMC10680849DOI
With Thais Klevorn · Immunology & Microbial Pathogenesis (PhD) · Class of 2025
Differentiating the roles of Mycobacterium tuberculosis substrate binding proteins, FecB and FecB2, in iron uptake.
PLoS pathogens · 2023
SESabine EhrtTKThaís Klevorn
PMID: 37747938PMCID: PMC10553834DOI8 citations
With Thais Klevorn · Immunology & Microbial Pathogenesis (PhD) · Class of 2025
Two interacting ATPases protect Mycobacterium tuberculosis from glycerol and nitric oxide toxicity.
Journal of bacteriology · 2020
SESabine EhrtTKThais KlevornMWMeredith WhitakerTHTravis HartmanKYKyu Y. Rhee
PMID: 32482725PMCID: PMC8404711DOI10 citations
With Thais Klevorn · Immunology & Microbial Pathogenesis (PhD) · Class of 2025
Two interacting ATPases protect Mycobacterium tuberculosis from glycerol and nitric oxide toxicity.
Journal of bacteriology · 2020
SESabine EhrtMWMeredith WhitakerTHTravis HartmanTKThais KlevornKYKyu Y. Rhee
PMID: 32482725PMCID: PMC8404711DOI10 citations
With Meredith Whitaker · Immunology & Microbial Pathogenesis (PhD) · Class of 2020
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy · 2017
SESabine EhrtWXWeizhen XuNRNadine RückerCACurtis A EngelhartMGMeredith G Wright+5 more →
PMID: 28893793PMCID: PMC5700314DOI92 citations
With Weizhen Xu · Immunology & Microbial Pathogenesis (PhD) · Class of 2017
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy · 2017
SESabine EhrtMGMeredith G WrightWXWeizhen XuNRNadine RückerCACurtis A Engelhart+5 more →
PMID: 28893793PMCID: PMC5700314DOI92 citations
With Meredith Whitaker · Immunology & Microbial Pathogenesis (PhD) · Class of 2020
Glyoxylate detoxification is an essential function of malate synthase required for carbon assimilation in Mycobacterium tuberculosis.
Proceedings of the National Academy of Sciences of the United States of America · 2017
SESabine EhrtSPSusan PuckettCTCarolina TrujilloZWZhe WangHEHyungjin Eoh+2 more →
PMID: 28265055PMCID: PMC5358392DOI85 citations
With Susan Puckett · Immunology & Microbial Pathogenesis (PhD) · Class of 2015
Fumarase Deficiency Causes Protein and Metabolite Succination and Intoxicates Mycobacterium tuberculosis.
Cell chemical biology · 2017
SESabine EhrtSPSusan PuckettNRNadine RueckerRJRobert JansenCTCarolina Trujillo+1 more →
PMID: 28219662PMCID: PMC5357164DOI47 citations
With Susan Puckett · Immunology & Microbial Pathogenesis (PhD) · Class of 2015
Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis.
mBio · 2017
SESabine EhrtWXWeizhen XuSWSae Woong Park DSDirk Schnappinger
PMID: 28096490PMCID: PMC5241402DOI528 citations
With Weizhen Xu · Immunology & Microbial Pathogenesis (PhD) · Class of 2017
Mycobacterium tuberculosis protease MarP activates a peptidoglycan hydrolase during acid stress.
The EMBO journal · 2017
SESabine EhrtWXWeizhen XuHBHelene BotellaJVJulien VaubourgeixMHMyung Hee Lee+1 more →
PMID: 28057704PMCID: PMC5437814DOI56 citations
With Weizhen Xu · Immunology & Microbial Pathogenesis (PhD) · Class of 2017
Two enzymes with redundant fructose bisphosphatase activity sustain gluconeogenesis and virulence in Mycobacterium tuberculosis.
Nature communications · 2015
SESabine EhrtUGUday GanapathySCSusannah CalhounHEHyungjin EohKYKyu Y. Rhee
PMID: 26258286PMCID: PMC4535450DOI58 citations
With Uday Ganapathy · Immunology & Microbial Pathogenesis (PhD) · Class of 2015
Inactivation of fructose-1,6-bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis.
PLoS pathogens · 2014
SESabine EhrtSPSusan PuckettCTCarolina TrujilloHEHyungjin EohDSDirk Schnappinger+1 more →
PMID: 24851864PMCID: PMC4031216DOI65 citations
With Susan Puckett · Immunology & Microbial Pathogenesis (PhD) · Class of 2015
Glycolytic and non-glycolytic functions of Mycobacterium tuberculosis fructose-1,6-bisphosphate aldolase, an essential enzyme produced by replicating and non-replicating bacilli.
The Journal of biological chemistry · 2011
SESabine EhrtSESusan E PuckettDSDirk Schnappinger
PMID: 21949126PMCID: PMC3220552DOI72 citations
With Susan Puckett · Immunology & Microbial Pathogenesis (PhD) · Class of 2015

Postdoc mentee

Non-canonical peptidoglycan cross-linking is essential for Mycobacterium tuberculosis acid resistance.
bioRxiv : the preprint server for biology · 2026
SESabine EhrtRMRuoyao MaAGAlexandre Gouzy
PMID: 41889872PMCID: PMC13015542DOI
With Ruoyao Ma · Postdoc mentee
Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation.
mBio · 2023
SESabine Ehrt YXYuanyuan Xu DSDirk Schnappinger
PMID: 38032200PMCID: PMC10746327DOI12 citations
With Yuanyuan Xu · Postdoc mentee
Synthetic lethality of Mycobacterium tuberculosis NADH dehydrogenases is due to impaired NADH oxidation.
bioRxiv : the preprint server for biology · 2023
SESabine Ehrt YXYuanyuan Xu DSDirk SchnappingerTBTiago Beites
PMID: 37090679PMCID: PMC10120654DOI
With Yuanyuan Xu · Postdoc mentee
Genetic models of latent tuberculosis in mice reveal differential influence of adaptive immunity.
The Journal of experimental medicine · 2021
SESabine EhrtYLYao LiuCHClaire HealyDSDirk Schnappinger
PMID: 34269789PMCID: PMC8289691DOI18 citations
With Yao Liu · Postdoc mentee
Depletion of the DarG antitoxin in Mycobacterium tuberculosis triggers the DNA-damage response and leads to cell death.
Molecular microbiology · 2020
SESabine EhrtRWRuojun WangAZAnisha ZaveriJBJoshua B Wallach+1 more →DSDirk Schnappinger
PMID: 32634279PMCID: PMC7689832DOI28 citations
With Ruojun Wang · Immunology & Microbial Pathogenesis · Class of 2019
Persistent Mycobacterium tuberculosis infection in mice requires PerM for successful cell division.
eLife · 2019
SESabine EhrtRWRuojun WangDSDirk Schnappinger
PMID: 31751212PMCID: PMC6872210DOI17 citations
With Ruojun Wang · Immunology & Microbial Pathogenesis · Class of 2019
Chemical Genetic Interaction Profiling Reveals Determinants of Intrinsic Antibiotic Resistance in Mycobacterium tuberculosis.
Antimicrobial agents and chemotherapy · 2017
SESabine EhrtRWRuojun WangWXWeizhen XuNRNadine RückerCACurtis A Engelhart+5 more →
PMID: 28893793PMCID: PMC5700314DOI92 citations
With Ruojun Wang · Immunology & Microbial Pathogenesis · Class of 2019
Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense.
PLoS pathogens · 2016
SESabine EhrtRWRuojun WangKLKan LinKMKathryn M O'BrienCTCarolina Trujillo+2 more →
PMID: 27249779PMCID: PMC4889078DOI61 citations
With Ruojun Wang · Immunology & Microbial Pathogenesis · Class of 2019
Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.
PLoS pathogens · 2015
SESabine EhrtRWRuojun WangNGNichole GoodsmithJVJulien VaubourgeixHBHélène Botella+1 more →
PMID: 25658098PMCID: PMC4450064DOI30 citations
With Ruojun Wang · Immunology & Microbial Pathogenesis · Class of 2019