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Li Gan, PhD
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Co-authored with Gillian Carling
Co-authored publications
Li Gan, PhD and Gillian Carling · 12 publications
CSV
Word
Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTD.
Communications biology
· 2025
LG
Li Gan
GC
Gillian Carling
CD
Claire Dudley Clelland
LF
Li Fan
JZ
Jingjie Zhu
+1 more →
PMID:
40596721
·
PMCID:
PMC12218935
·
DOI
·
2 citations
·
Abstract
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
Neuron
· 2024
LG
Li Gan
GK
Gillian K Carling
LF
Li Fan
NF
Nessa Foxe
DZ
Daphne Zhu
+9 more →
PMID:
39353433
·
PMCID:
PMC11624100
·
DOI
·
68 citations
·
Abstract
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
Cell
· 2024
LG
Li Gan
GK
Gillian K Carling
CP
Celeste Parra Bravo
AM
Alice Maria Giani
YW
Yuansong Wan
+7 more →
PMID:
38582079
·
PMCID:
PMC11365117
·
DOI
·
60 citations
·
Abstract
Mechanisms of sex differences in Alzheimer's disease.
Neuron
· 2024
LG
Li Gan
GC
Gillian Carling
CL
Chloe Lopez-Lee
ER
Eileen Ruth S Torres
PMID:
38402606
·
PMCID:
PMC11076015
·
DOI
·
332 citations
·
Abstract
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.
bioRxiv : the preprint server for biology
· 2024
LG
Li Gan
GK
Gillian K Carling
LF
Li Fan
NF
Nessa Foxe
HC
Hao Chen
+5 more →
PMID:
38328219
·
PMCID:
PMC10849737
·
DOI
·
Abstract
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
Research square
· 2023
LG
Li Gan
GC
Gillian Carling
HC
Hao Chen
LF
Li Fan
+5 more →
WL
Wenjie Luo
PMID:
37961627
·
PMCID:
PMC10635319
·
DOI
·
Abstract
DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity.
bioRxiv : the preprint server for biology
· 2023
LG
Li Gan
GC
Gillian Carling
HC
Hao Chen
LF
Li Fan
+5 more →
WL
Wenjie Luo
PMID:
37961594
·
PMCID:
PMC10634844
·
DOI
·
Abstract
Human iPSC 4R tauopathy model uncovers modifiers of tau propagation.
bioRxiv : the preprint server for biology
· 2023
LG
Li Gan
GC
Gillian Carling
CP
Celeste Parra Bravo
AM
Alice Maria Giani
ZZ
Zeping Zhao
+6 more →
PMID:
37745431
·
PMCID:
PMC10516028
·
DOI
·
Abstract
Tau activation of microglial cGAS-IFN reduces MEF2C-mediated cognitive resilience.
Nature neuroscience
· 2023
LG
Li Gan
GK
Gillian K Carling
SA
Sadaf Amin
YH
Yige Huang
LF
Li Fan
+8 more →
PMID:
37095396
·
PMCID:
PMC10166855
·
DOI
·
237 citations
·
Abstract
Friend turned foe: TREM2 agonist in battles against tau.
The Journal of experimental medicine
· 2022
LG
Li Gan
GC
Gillian Carling
WL
Wenjie Luo
PMID:
36399126
·
PMCID:
PMC9680035
·
DOI
·
9 citations
·
Abstract
AD-linked R47H-
TREM2
mutation induces disease-enhancing microglial states via AKT hyperactivation.
Science translational medicine
· 2021
LG
Li Gan
GK
Gillian K Carling
LF
Li Fan
XN
Xiang Niu
MB
Matthew Brendel
+4 more →
PMID:
34851693
·
PMCID:
PMC9345574
·
DOI
·
110 citations
·
Abstract
New insights and therapeutic opportunities for progranulin-deficient frontotemporal dementia.
Current opinion in neurobiology
· 2021
LG
Li Gan
GC
Gillian Carling
SA
Sadaf Amin
PMID:
34826653
·
DOI
·
25 citations
·
Abstract