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Scholars/Jedd D Wolchok, PhD, MD/Co-authored with mentees

Co-authored publications with mentees

Jedd D Wolchok, PhD, MD · 21 publications across 9 mentees

MD mentee

Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.
Cell reports · 2026
JDJedd D WolchokSEShabnam EghbaliCWChien-Huan WengCSChana Schochet+8 more →TMTaha Merghoub
PMID: 42213780DOI1 citations
With Shabnam Eghbali · MD mentee · Class of 2023
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.
Science translational medicine · 2022
JDJedd D WolchokJJJoseph J ParkRZRoberta Zappasodi DRDavid Redmond+8 more →TMTaha Merghoub
PMID: 35704596PMCID: PMC11182673DOI31 citations
With Joseph Park · MD mentee · Class of 2019
Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer.
Communications biology · 2021
JDJedd D WolchokAGAditi GuptaSBSadna BudhuAHAliya HollandTMTaha Merghoub
PMID: 34789823PMCID: PMC8599839DOI15 citations
With Aditi Gupta · MD mentee · Class of 2019
Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways.
Nature reviews. Clinical oncology · 2021
JDJedd D WolchokSEShabnam EghbaliCWChien-Huan Weng TMTaha Merghoub
PMID: 34580473DOI764 citations
With Shabnam Eghbali · MD mentee · Class of 2023
Tim-4⁺ cavity-resident macrophages impair anti-tumor CD8⁺ T cell immunity.
Cancer cell · 2021
JDJedd D WolchokAGAditi GuptaSSSara SchadDZDmitriy Zamarin+7 more →TMTaha Merghoub
PMID: 34115989PMCID: PMC9115604DOI172 citations
With Aditi Gupta · MD mentee · Class of 2019
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports · 2021
JDJedd D WolchokAGAditi GuptaSBSadna Budhu RZRoberta Zappasodi+3 more →TMTaha Merghoub
PMID: 33440157PMCID: PMC8100747DOI49 citations
With Aditi Gupta · MD mentee · Class of 2019
In situ vaccination with defined factors overcomes T cell exhaustion in distant tumors.
The Journal of clinical investigation · 2019
JDJedd D WolchokAGAditi GuptaSBSadna Budhu DRDavid Redmond+5 more →TMTaha Merghoub
PMID: 31329159PMCID: PMC6668692DOI43 citations
With Aditi Gupta · MD mentee · Class of 2019

PhD mentee

Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.
The Journal of experimental medicine · 2026
JDJedd D Wolchok JFJonathan F. KhanADAlyssa Duren-LubanskiWCWinson Cai+7 more →TMTaha Merghoub
PMID: 42360231DOI1 citations
With Jonathan F. Khan · Pharmacology (PhD) · Class of 2023
Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.
Cell reports · 2026
JDJedd D Wolchok JFJonathan F. Khan CWChien-Huan WengCSChana Schochet+8 more →TMTaha Merghoub
PMID: 42213780DOI1 citations
With Jonathan F. Khan · Pharmacology (PhD) · Class of 2023
Effective PD-1 checkpoint blockade in bladder cancer model requires tumor-draining lymph nodes and lymphocyte trafficking.
Urologic oncology · 2026
JDJedd D Wolchok JFJonathan F. KhanJCJuan C Angulo-LozanoLPLina Posada-Calderon+6 more →DSDouglas S Scherr
PMID: 42167990DOI
With Jonathan F. Khan · Pharmacology (PhD) · Class of 2023
Thrombospondin-1-CD47 signaling contributes to the development of T cell exhaustion in cancer.
Nature immunology · 2025
JDJedd D Wolchok JFJonathan F. Khan CWChien-Huan Weng AAAnais Assouvie+9 more →TMTaha Merghoub
PMID: 41249483PMCID: PMC13536922DOI14 citations
With Jonathan F. Khan · Pharmacology (PhD) · Class of 2023
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.
The Journal of clinical investigation · 2024
JDJedd D Wolchok JFJonathan F. KhanSVSvena VermaSBSadna Budhu+5 more →TMTaha Merghoub
PMID: 39225102PMCID: PMC11364391DOI86 citations
With Jonathan F. Khan · Pharmacology (PhD) · Class of 2023
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.
The Journal of clinical investigation · 2024
JDJedd D WolchokSVSvena VermaSBSadna Budhu ISInna Sergeevna Serganova+5 more →TMTaha Merghoub
PMID: 39225102PMCID: PMC11364391DOI86 citations
With Svena Verma · Pharmacology (PhD) · Class of 2024
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.
The Journal of clinical investigation · 2024
JDJedd D WolchokMBMamadou BahSVSvena VermaSBSadna Budhu+5 more →TMTaha Merghoub
PMID: 39225102PMCID: PMC11364391DOI86 citations
With Mamadou Bah · Immunology & Microbial Pathogenesis (PhD)
Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.
Cancer immunology research · 2024
JDJedd D Wolchok JFJonathan F. KhanLDLauren DongSBSadna Budhu+4 more →TMTaha Merghoub
PMID: 38885362PMCID: PMC12679059DOI7 citations
With Jonathan F. Khan · Pharmacology (PhD) · Class of 2023
Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.
Cancer immunology research · 2024
JDJedd D WolchokSVSvena VermaLDLauren DongSBSadna Budhu+4 more →TMTaha Merghoub
PMID: 38885362PMCID: PMC12679059DOI7 citations
With Svena Verma · Pharmacology (PhD) · Class of 2024
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.
Cancer cell · 2023
JDJedd D WolchokSVSvena VermaTMTaha Merghoub
PMID: 37327788PMCID: PMC11161201DOI179 citations
With Svena Verma · Pharmacology (PhD) · Class of 2024
Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.
Science translational medicine · 2022
JDJedd D WolchokSVSvena VermaRZRoberta ZappasodiJJJoseph J Park+8 more →TMTaha Merghoub
PMID: 35704596PMCID: PMC11182673DOI31 citations
With Svena Verma · Pharmacology (PhD) · Class of 2024
Tim-4⁺ cavity-resident macrophages impair anti-tumor CD8⁺ T cell immunity.
Cancer cell · 2021
JDJedd D WolchokSSSara SchadDZDmitriy ZamarinSBSadna Budhu+7 more →TMTaha Merghoub
PMID: 34115989PMCID: PMC9115604DOI172 citations
With Sara Schad · Immunology & Microbial Pathogenesis (PhD) · Class of 2021
CTLA-4 blockade drives loss of T_reg stability in glycolysis-low tumours.
Nature · 2021
JDJedd D WolchokSVSvena VermaRZRoberta Zappasodi ISInna Sergeevna Serganova+3 more →TMTaha Merghoub
PMID: 33588426PMCID: PMC8057670DOI356 citations
With Svena Verma · Pharmacology (PhD) · Class of 2024
Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma.
Cell reports · 2021
JDJedd D WolchokSSSara SchadSBSadna BudhuAGAditi Gupta+3 more →TMTaha Merghoub
PMID: 33440157PMCID: PMC8100747DOI49 citations
With Sara Schad · Immunology & Microbial Pathogenesis (PhD) · Class of 2021
Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.
Immunity · 2016
JDJedd D WolchokNMNicole MalandroSBSadna BudhuJTJudith T MurphyGRGabrielle Rizzuto+1 more →
PMID: 26789923PMCID: PMC4996670DOI44 citations
With Nicole Malandro · Immunology & Microbial Pathogenesis (PhD) · Class of 2016
Clonal Abundance of Tumor-Specific CD4(+) T Cells Potentiates Efficacy and Alters Susceptibility to Exhaustion.
Immunity · 2016
JDJedd D WolchokJTJudith T MurphyNMNicole MalandroSBSadna BudhuGRGabrielle Rizzuto+1 more →
PMID: 26789923PMCID: PMC4996670DOI44 citations
With Judith Murphy · Immunology & Microbial Pathogenesis (PhD) · Class of 2015
The New Era of Cancer Immunotherapy: Manipulating T-Cell Activity to Overcome Malignancy.
Advances in cancer research · 2015
JDJedd D WolchokJTJudith T MurphyDNDanny Nejad Khalil SBSadna Budhu+3 more →TMTaha Merghoub
PMID: 26216629DOI45 citations
With Judith Murphy · Immunology & Microbial Pathogenesis (PhD) · Class of 2015
Combination of alphavirus replicon particle-based vaccination with immunomodulatory antibodies: therapeutic activity in the B16 melanoma mouse model and immune correlates.
Cancer immunology research · 2014
JDJedd D WolchokNMNicole MalandroRZRoberta Zappasodi SBSadna Budhu+1 more →TMTaha Merghoub
PMID: 24795357PMCID: PMC4406637DOI48 citations
With Nicole Malandro · Immunology & Microbial Pathogenesis (PhD) · Class of 2016
T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks.
eLife · 2014
JDJedd D WolchokNMNicole MalandroJWJesse W CotariTMTaha Merghoub
PMID: 24719192PMCID: PMC3980879DOI53 citations
With Nicole Malandro · Immunology & Microbial Pathogenesis (PhD) · Class of 2016
Anaphylaxis caused by repetitive doses of a GITR agonist monoclonal antibody in mice.
Blood · 2014
JDJedd D WolchokJTJudith T MurphyTMTaha Merghoub
PMID: 24558202PMCID: PMC3975257DOI31 citations
With Judith Murphy · Immunology & Microbial Pathogenesis (PhD) · Class of 2015
GITR pathway activation abrogates tumor immune suppression through loss of regulatory T cell lineage stability.
Cancer immunology research · 2013
JDJedd D WolchokNMNicole MalandroSBSadna BudhuANAlan N HoughtonTMTaha Merghoub
PMID: 24416730PMCID: PMC3885345DOI144 citations
With Nicole Malandro · Immunology & Microbial Pathogenesis (PhD) · Class of 2016
Modulation of GITR for cancer immunotherapy.
Current opinion in immunology · 2012
JDJedd D WolchokJTJudith T Murphy
PMID: 22245556PMCID: PMC3413251DOI127 citations
With Judith Murphy · Immunology & Microbial Pathogenesis (PhD) · Class of 2015