Co-authored publications

Jedd D Wolchok, PhD, MD and Jonathan Khan · 6 publications

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Intravesical mesothelin-based CAR T cells targeting MUC16 effectively control bladder cancer in preclinical models.
The Journal of experimental medicine · 2026
JDJedd D Wolchok JFJonathan F. KhanADAlyssa Duren-LubanskiWCWinson Cai+7 more →TMTaha Merghoub
PMID: 42360231DOI1 citations
Tumor-intrinsic expression of signal regulatory protein α contributes to the suppression of anti-tumor immune responses.
Cell reports · 2026
JDJedd D Wolchok JFJonathan F. Khan CWChien-Huan WengCSChana Schochet+8 more →TMTaha Merghoub
PMID: 42213780DOI1 citations
Effective PD-1 checkpoint blockade in bladder cancer model requires tumor-draining lymph nodes and lymphocyte trafficking.
Urologic oncology · 2026
JDJedd D Wolchok JFJonathan F. KhanJCJuan C Angulo-LozanoLPLina Posada-Calderon+6 more →DSDouglas S Scherr
PMID: 42167990DOI
Thrombospondin-1-CD47 signaling contributes to the development of T cell exhaustion in cancer.
Nature immunology · 2025
JDJedd D Wolchok JFJonathan F. Khan CWChien-Huan Weng AAAnais Assouvie+9 more →TMTaha Merghoub
PMID: 41249483PMCID: PMC13536922DOI14 citations
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.
The Journal of clinical investigation · 2024
JDJedd D Wolchok JFJonathan F. KhanSVSvena VermaSBSadna Budhu+5 more →TMTaha Merghoub
PMID: 39225102PMCID: PMC11364391DOI86 citations
Intermittent MEK Inhibition with GITR Costimulation Rescues T-cell Function for Increased Efficacy with CTLA-4 Blockade in Solid Tumor Models.
Cancer immunology research · 2024
JDJedd D Wolchok JFJonathan F. KhanLDLauren DongSBSadna Budhu+4 more →TMTaha Merghoub
PMID: 38885362PMCID: PMC12679059DOI7 citations