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ScholarsBetaWeill Cornell Medicine

Overview

Mechanisms of Neuroprotection

My lab uses biochemical and cellular biology approaches to study neuronal cell death and the mechanism of neuroprotection. Mitochondria are important cellular organelles that regulate the life and death of the cells under stress. The mitochondria from our animal models of neuroprotection are enhanced against insults. We are interested in understanding the biochemical and molecular basis of this mitochondria mediated cell viability enhancement. We are also investigating the signaling processes leading to the cell viability enhancement, such as iNOS and Cox-2 induction. For more information, please visit our website at: http://www.cornellneurology.org/neurobiology

Highlights

  1. 1
    The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020
    GMGiovanni ManfrediCICostantino IadecolaPZPing Zhou
    PMID: 32152200PMCID: PMC7159891DOISenior author20 citations

Publications

95 publications

Funding

9 grantsView NIH portfolio on RePORTER ↗

Active

3 grants
  • Co-I
    Dietary sodium, neurovascular dysfunction and cerebrovascular risk
    National Institute of Neurological Disorders and Stroke · 2015–2027· 2 renewals
    R01NS095441-06
  • PI
    Role of prohibitin nitrosylation in its neuroprotective functions
    National Institute of Neurological Disorders and Stroke · 2022–2027
    R01NS128034-05
  • Co-I
    ApoE4, neurovascular injury and cognitive impairment
    National Institute of Neurological Disorders and Stroke · 2022–2027
    R01NS126467-01
Completed grants (6)
  • Co-I
    Aberrant Prefrontal Cortical Plasticity and Neurobehavioral Consequences of Adolescent Marijuana
    National Institute on Drug Abuse · 2017–2023
    R01DA042943-05
  • Co-I
    Overexpression of the Amyloid Precursor Protein and Cerebrovascular Regulation
    National Institute of Neurological Disorders and Stroke · 2017–2022
    R01NS037853-20
  • Co-I
    Contribution of Estrogen Receptor Beta to Changes in Hypothalamic Plasticity and Hypertension Susceptibility in Mice With Accelerated Ovarian Failure
    National Heart, Lung, and Blood Institute · 2017–2022
    R01HL136520-02
  • PI
    Role of prohibitin in ischemic brain injury
    National Institute of Neurological Disorders and Stroke · 2020–2022
    R56NS067078-11A1
  • Co-I
    Estrogen Receptor Beta and Mitochondrial Permeability Transition in Ca2+-Induced Neuronal Injury
    National Institute of Neurological Disorders and Stroke · 2016–2022
    R01NS095692-03
  • PI
    Role of Prohibitin in Ischemic Brain Injury
    National Institute of Neurological Disorders and Stroke · 2009–2020· 2 renewals
    R01NS067078-10

Available technologies

1 technologyView full WCM portfolio ↗