Matthew Blake Greenblatt, PhD, MD

Associate Professor of Pathology and Laboratory Medicine

Pathology and Laboratory Medicine

Contact & profiles

Appointments

Associate Professor of Pathology and Laboratory MedicinePrimary
Pathology and Laboratory Medicine · 2020–
Rohr Family Research Scholar
Pathology and Laboratory Medicine · 2025–
Physician
NewYork-Presbyterian Hospital

Past Appointments

Assistant Professor of Pathology and Laboratory Medicine
Pathology and Laboratory Medicine · 2015–2020
Visiting Fellow in Pathology and Laboratory Medicine
Pathology and Laboratory Medicine · 2015–2015

Centers

Clinical & Translational Science Center
Sandra and Edward Meyer Cancer Centerresearch
Cancer Biology
Weill Center for Metabolic Health

Education

M.D.
Harvard Medical School, 2012
Ph.D.
Harvard Medical School, 2010
B.S., M.S.
Yale University, 2004

Highlights

1
Nature · 2023
SBSeoyeon Bok KMKyle Morse VMVivek Mittal MBMathias Bostrom+1 more →MBMatthew Blake Greenblatt
PMID: 37704733PMCID: PMC10829697DOISenior author78 citations
2
Nature · 2023
SBSeoyeon Bok KMKyle Morse DJDavid J Pisapia SLShenela Lakhani+2 more →MBMatthew Blake Greenblatt
PMID: 37730988PMCID: PMC10799660DOISenior author77 citations
3
Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024
KMKyle Morse HSHe Sarina Yang SISravisht Iyer MBMatthew Blake Greenblatt
PMID: 38245845DOISenior author21 citations

Publications

125

Funding

28 View NIH portfolio on RePORTER ↗

Active

12 grants

Sub-PI
Aging-Related Hematopoetic Stem Cell Intrinsic and Microenvironmental Signals in AML Transformation (Core A)
National Cancer Institute · 2024–2029 · via Columbia University· 2 renewals
P01CA285250-02
PI
Discovery of a stem cell governing vertebral physiology
National Inst of Arthritis & Musculoskeletal & Skin Diseases · 2024–2029
R01AR083462-03
PI
Discovery of a stem cell driving breast cancer spine metastases
National Cancer Institute · 2024–2029
R01CA282815-02
MPI
A skeletal stem cell orchestrating limb regeneration
Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2024–2029
R01HD115274-03
Co-I
Next-Gen Oncopathology Program
National Cancer Institute · 2022–2027Training
T32CA260293-01A1
KP
A stem cell basis for NF1-associated skeletal manifestations
Children's Tumor Foundation · 2025–2027
CTF 250085-01
PI
Discovery of the articular cartilage stem cell
The G. Harold and Leila Y. Mathers Foundation · 2024–2027
HLMF 242466-03
KP
A calvarial stem cell mediating a new bone-brain axis in Alzheimer's disease
National Institute on Aging · 2025–2027Career
K99AG090732-01
PI
Skeletal Stem Cell Niche Dysfunction in Marfan Syndrome
National Marfan Foundation · 2024–2026
NMF 234686-02
PI
New Approaches to Target Vertebral Metastases in Breast Cancer
Mary Kay Foundation, The · 2023–2026
MKF 233277-02
PI
A Bone to Brain Axis Controlling Alzheimer's Disease Progression
Pershing Square Foundation · 2023–2026
PSE 231873-03
Sub-PI
Biology of cortical bone of long bones and calvarium: Role of Sfrp4 in periosteal bone formation
National Institute of Dental and Craniofacial Research · 2020–2026 · via Harvard School of Dental Medicine
R01DE029615-05

Completed grants (16)

PI
Novel Mechanisms of Bone Formation
Burroughs Wellcome Fund · 2015–2025
1014758
PI
"Establishing Pathways for Endothelial Support of Bone Formation with SLIT3"
National Inst of Arthritis & Musculoskeletal & Skin Diseases · 2020–2025
R01AR075585-05
Sub-PI
Tumor-Selective Delivery Approaches for Medulloblastoma
National Institute of Neurological Disorders and Stroke · 2020–2024 · via Memorial Sloan Kettering Cancer Center
R01NS116353-04
PI
A novel calvarial stem cell regulating glioblastoma anti-tumor immunity
William Rhodes Center for Glioblastoma - Collaborative Research Initiative · 2023–2024
WRCG 235233-01
Sub-PI
Treat Implant loosening of Percutaneous Osseointegrated Prosthetic Limbs with Intermittent Parathyroid Hormone
U.S. Department of Defense · 2021–2024 · via Hospital for Special Surgery
W81XWH-21-1-0900
PI
Novartis BioPharma Alliance Agreemeent
Novartis Insitutes for BioMedical Research · 2021–2024BioPharma Alliance
NA 212810-01
PI
Targeting Skeletal Stem Cells to Treat Tumor-induced Osteolysis
Pershing Square Sohn Cancer Research Alliance · 2019–2023
PSS 200391-03
PI
stem cell basis for bone microarchitecture, materials properties, and anabolic responses to loading
Weill Cornell Medical College · 2021–2021
WCMC 211708-01
Co-I
Investigation of the Roles for CaV1.2 in Non-Excitable Tissue During Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2016–2021
R01HD090132-03
PI
Modulation of Bone Formation by SHN3
Office of the Director, NIH · 2015–2020
DP5OD021351-05
PI
Treating Tumor-Mediated Osteolysis with SHN3 Inhibition
Daedalus Fund for Innovation (Weill Cornell) · 2018–2020
DFI 183606-02
PI
Defining the Role of a Novel Periosteal Mesenchymal Stem Cell in Skeletal Morphogenesis and Development
March of Dimes · 2017–2019
5-FY17-29
PI
Assessment of MEKK2 as a Novel Therapeutic Target in Neurofibromatosis
U.S. Department of Defense · 2016–2018
W81XWH-16-1-0398
Sub-PI
Identification and Characterization of Bone-Related Genetic Variants in Families
Qatar National Research Fund · 2015–2018 · via Hamad Medical Corporation
NPRP 7-1301-3-336
PI
Promoting Skeletal Healing Through the Schnurri-3 Pathway
Musculoskeletal Transplant Foundation, Inc. · 2016–2017
MTF 16030353-01 EWOF
Sub-PI
Identification of Novel Regulators Governing Osteoclast-Osteoblast Coupling
National Inst of Arthritis & Musculoskeletal & Skin Diseases · 2016–2017 · via University of Massachusetts Medical Center
R01AR068983-02

Honors & distinctions

Member · American Society for Clinical Investigation · 2021
Career Award · Burroughs Wellcome Fund · 2015
Member · Association of American Physicians

Available technologies

1 View full WCM portfolio ↗

Targeting the SLIT3 Pathway to Promote Bone Formation
Application filedPoC DataPMID 29785024
7658

News mentions

5 View all WCM news ↗

Dr. Matthew Greenblatt Awarded Paul-Gallin Trailblazer Prize for Bone Stem Cell Discoveries
August 21, 2025
The award recognizes Dr. Greenblatt's discovery of distinct types of bone-building stem cells in different parts of the body.
Weill Cornell Medicine Faculty Inducted into Association of American Physicians
April 28, 2025
Three distinguished Weill Cornell Medicine physician-scientists, Dr. Matthew Greenblatt, Dr. Lishomwa Ndhlovu and Dr. Sallie Permar, have been elected to the prestigious Association of American Physicians (AAP).
Study Reveals Why Cancer May Spread To The Spine
September 13, 2023
The vertebral bones that form the spine are derived from a distinct type of stem cell that secretes a protein favoring tumor metastases, according to a study led by researchers at Weill Cornell Medicine.
Dr. Matthew Greenblatt Wins Pershing Square Foundation’s Inaugural MIND Prize
April 25, 2023
Dr. Matthew Greenblatt, an associate professor of pathology and laboratory medicine at Weill Cornell Medicine, has been awarded the Pershing Square Foundation’s Maximizing Innovation in Neuroscience Discovery (MIND) Prize to support his work studying how bone cells may influence Alzheimer’s disease progression.
Finding May Lead to New Treatments for Neurofibromatosis
November 20, 2020
Common symptoms of the genetic disorder neurofibromatosis type 1 (NF1), including skeletal fragility and the loss of bone mass, may be treatable with an existing anti-cancer drug, according to a study from researchers at Weill Cornell Medicine.