Highlights
- 1Cancer cell · 2020
- 2Molecular cell · 2024
- 3
Publications
Funding
Active
3 grants- PIR01CA275846-04Cholesterol Metabolism in Mesenchymal Colorectal CancerNational Cancer Institute · 2022–2027
- PIR01CA265892-05Interferon regulation by NBR1-driven chaperone-mediated autophagy in stellate cells in liver cancerNational Cancer Institute · 2021–2027
- PIR01CA250025-05Molecular mechanisms driving mesenchymal colorectal cancerNational Cancer Institute · 2021–2026
Completed grants (12)
- Co-IR01CA246765-01Novel Pathways in the Control of Lineage Plasticity in Neuroendocrine Prostate CancerNational Cancer Institute · 2020–2025
- PIAddgene 698073Addgene 698073Addgene, Inc. · 2022–2023
- PIAddgene 700828Addgene 700828Addgene, Inc. · 2022–2023
- PIR01DK108743-05Control of stellate cells-driven liver cancer by the p62/NBR1 adaptersNational Institute of Diabetes and Digestive and Kidney Diseases · 2020–2022
- PIR01CA207177-04Mechanisms of cell death and autophagy in intestinal epithelial cells in inflammation and cancerNational Cancer Institute · 2020–2022
- MPIR01CA211794-05Role of p62/SQSTM1 in obesity-induced liver cancerNational Cancer Institute · 2020–2022 · via University of California, San Diego
- Sub-PISBP 210103-02PhgdhLeidos Biomedical Research · 2020–2020 · via Sanford Burnham Prebys Medical Discovery Institute
- PIR01CA172025-05Protein Kinase Cz targets in Intestinal Cancer Stem CellsNCI · 2013–2018 · via NIH RePORTER
- PIR01CA132847-05Role and mechanism of action of p62/Sqstm1 in Ras-induced tumorigenesis in lungNCI · 2009–2015 · via NIH RePORTER
- PIR01DK088107-04Obesity-Induced Inflammation and Insulin Resistance by the p62/PKCzeta SignalingNIDDK · 2010–2014 · via NIH RePORTER
- PIR01AI072581-05The p62/atypical PKC signaling complex in Th2 differentiation and asthmaNIAID · 2008–2013 · via NIH RePORTER
Clinical research
Active
1 study- PIDetermining the clinical relevance of p62 and NBR1 in HSCs in Hepatocellular CarcinomaMayo Clinic · OPEN TO ACCRUAL (as of 2020)
Available technologies
- Improving the Efficacy of PARP1 Inhibitors by Targeting the Tumor Stroma10168PCT filedPoC DataPMID 35545049
News mentions
- Study Unveils Key Strategies Against Drug-Resistant Prostate CancerNovember 20, 2024
An enzyme called EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers, according to a new study by scientists at Weill Cornell Medicine.
- Biomarker May Predict Immunotherapy Response in Liver CancerOctober 17, 2024
It may soon be possible to determine which patients with a type of liver cancer called hepatocellular carcinoma would benefit from immunotherapy, according to a preclinical study by Weill Cornell Medicine investigators.
- Identifying the Initial Steps in Colorectal Cancer FormationMay 29, 2024
Research led by Weill Cornell Medicine provides new evidence that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear.
- Cholesterol-Lowering Therapy May Hinder Aggressive Type of Colorectal TumorDecember 13, 2023
Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine.
- Potential Therapy for an Aggressive Type of Colon Cancer Identified in Preclinical StudiesDecember 15, 2022
An experimental therapy showed promise as treatment for an aggressively spreading type of colorectal cancer in preclinical models.
Show 6 more mentions
- Potential Therapy for Metastatic Colon Cancer Identified in Preclinical StudiesDecember 15, 2022
An experimental therapy showed promise as treatment for an aggressively spreading type of colorectal cancer in...
- Tumor Release of Lactate Forces Nearby Cells into Supportive RoleMay 9, 2022
Tumors can force neighboring cells into supporting cancer growth by releasing lactate into their local environment, according to researchers at Weill Cornell Medicine.
- Enhancing Immune System Discovery of Tumors Might Combat Colorectal CancerSeptember 23, 2021
Turning off a defense mechanism that protects colorectal cancer tumors from being discovered by immune cells could be a possible strategy for treating the disease.
- Scientists Gain Insight into the Mechanisms of Fat Burning and StorageMay 17, 2021
A new understanding of the interaction of two proteins and their role in fat burning and storage may one day have implications for the treatment of obesity and associated diseases such as diabetes and cancer, according to Weill Cornell Medicine investigators.
- Research Reveals Why Some Tumors Have Different Makeup of CellsNovember 20, 2020
Molecular changes in cells called fibroblasts, which help provide support for tissues throughout the body, may explain why one type of colon cancer doesn’t respond to therapy.
- Enzyme Blocks Metabolic Processes that Spur Rapid Growth and Spread of Liver CancerJune 25, 2020
An enzyme has been discovered to play a critical role in blocking the metabolic processes that contribute to the rapid growth and spread of liver cancer, according to a new study by Weill Cornell Medicine researchers.
Mentoring
Postdoc · 8
- MRMarc Ruiz MartinezPostdoc mentee · 2020–2026
- SNSadaaki NishimuraPostdoc mentee · 2021–2025
- YSYuto ShingaiPostdoc mentee · 2021–2024
- HKHiroto KinoshitaPostdoc mentee · 2020–2023
- YMYu MutaPostdoc mentee · 2020–2023