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ScholarsBetaWeill Cornell Medicine

Overview

Prof. Ketterling’s research is focused on the development and translation of ultrasound technology to basic science, small-animal and clinical applications. He has over 25 years of research experience in ultrasound imaging and therapy topics primarily supported through National Institutes grant awards.

Prof. Ketterling has worked extensively with high-frequency ultrasound (> 20 MHz). He developed and patented a method of fabricating annular-array transducers and designed imaging platforms for ophthalmic human subject use and studies of in utero mouse embryonic central nervous system development. The work was extended to in vivo photoacoustic imaging of mouse embryos. The transducer technology was licensed for ophthalmic ultrasound imaging.

More recently, Dr, Ketterling has shifted into a new research area focused on high-speed plane-wave ultrasound imaging. The technology was applied to several applications including intracardiac flow patterns in mouse embryos and adult mice, blood flow in the front and back of the human eye, and activation of acoustic nanodrops for imaging microcirculation using methods such as super-resolution localization microscopy.

Highlights

  1. 1
    Ultrasound in medicine & biology · 2022
    JKJeffrey Ketterling
    PMID: 35125244PMCID: PMC8983467DOISenior author21 citations
  2. 2
    IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    JKJeffrey Ketterling
    PMID: 32763851PMCID: PMC8054309DOISenior author6 citations
  3. 3
    Translational vision science & technology · 2023
    CHCameron HoerigJMJonathan MamouJKJeffrey Ketterling
    PMID: 37750745PMCID: PMC10540872DOISenior author3 citations

Publications

89 publications

Funding

16 grantsView NIH portfolio on RePORTER ↗

Active

4 grants
  • PI
    3-D Volumetric & 4-D Dynamic Ultrasonography to Quantify Vitreous Structure and Mobility
    NEI · 2026–2030 · via NIH RePORTER
    R01EY038751-01
  • MPI
    Transcranial Doppler array for automated ultrasound emboli detection with deep learning
    National Institute of Biomedical Imaging and Bioengineering · 2026–2030
    R01EB037051-01A1
  • PI
    Murine cardiac vector-flow imaging with high-frequency 2D row-column CMUT arrays
    National Heart, Lung, and Blood Institute · 2022–2027
    R01HL159869-04
  • Co-I
    Next Generation Quantitative Acoustic Microscopy for Biomedical Application
    National Institute of General Medical Sciences · 2022–2027
    R01GM143388-04
Completed grants (12)
  • PI
    Improving cervical cancer patient treatment and outcomes with the development of a modernized, novel gynecologic brachytherapy device
    American Cancer Society · 2024–2025
    EDS-24-1333815-01-EDS
  • PI
    Vitreo-retinal disease imaging with 3D annular-array ultrasound
    National Institute of Biomedical Imaging and Bioengineering · 2022–2025
    R01EB032082-02
  • PI
    Engineering in Cardiovascular Health, Disease, and Treatment
    Cornell University · 2023–2024
    CUI 235504-01
  • Co-I
    Novel in-vivo ultrasound-based point-of-care instrument to assess myopia level and progression
    National Institute of Biomedical Imaging and Bioengineering · 2023–2024
    No publications yet
    R21EB028084-02
  • PI
    Fine-resolution mapping of micro vasculature after placental transport of acoustic nanodrops
    NICHD · 2019–2022 · via NIH RePORTER
    R21HD097485-02
  • PI
    In utero mouse embryo phenotyping with high-frequency ultrasound
    NIBIB · 2016–2021 · via NIH RePORTER
    R01EB022950-04
  • PI
    Quantitative characterization of vitreous degeneration in myopia
    NEI · 2015–2016 · via NIH RePORTER
    R21EY024434-02
  • PI
    Acoustic Contrast Agents for Use with High-frequency Ultrasound
    NIBIB · 2008–2013 · via NIH RePORTER
    R01EB006372-04
  • PI
    High-frequency-ultrasound annular arrays for ophthalmic and small-animal imaging
    NIBIB · 2008–2012 · via NIH RePORTER
    R01EB008606-04
  • PI
    Advanced acoustic field measurements of shock wave lithotripters
    NIDDK · 2009–2012 · via NIH RePORTER
    R21DK081119-02
  • PI
    Fifth Conference on Ultrasonic Biomicroscopy 2006
    NIBIB · 2006–2007 · via NIH RePORTER
    R13EB006265-01A1
  • PI
    VERY-HIGH-FREQUENCY ULTRASOUND ARRAYS FOR OPHTHALMOLOGY
    NEI · 2003–2007 · via NIH RePORTER
    R03EY014371-03

Honors & distinctions

3 honors
  • Distinguished Investigator · Academy for Radiology & Biomedical Imaging Research · 2022
  • Fellow · American Institute of Ultrasound in Medicine · 2019
  • Fellow · Acoustical Society of America · 2015

Clinical research

1 study

Active

1 study
  • PI
    3D Ultrasound Imaging of Vitreous and Retina with a Row-Column Array
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)

Available technologies

1 technologyView full WCM portfolio ↗

Mentoring

3 menteesAll publications with mentees →