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ScholarsBetaWeill Cornell Medicine

Overview

The overarching goal of Dr. Stout-Delgado's research is to integrate multiple fields—lung biology, microbiology, immunology, and bioinformatics—to elucidate the cellular mechanisms underlying the hyperactivation of alveolar macrophages, infiltrating monocytes, and neutrophils, which contribute to tissue damage and disease progression. Using young and aged adult murine models,  as well as clinical samples, her current research interests include: (1) Understanding how the process of aging alters innate immune signaling pathways to bacterial and viral pathogens; (2) Investigating the impact of aging on mitochondria, endoplasmic reticulum (ER), and ER-mitochondrial communication and how these changes contribute to increased host susceptibility to acute lung injury and pneumonia; (3) Examining age-associated alterations in lipid metabolism and the impact of these changes on innate immune signaling cascades and cytokine release syndrome development; (4) Developing and characterizing compounds and therapeutic strategies to improve morbidity and mortality in aging populations during primary or secondary pulmonary infections. Special focus for these studies will be on in vitro and in vivo infection models using influenza (H3N2 and H1N1 strains), S. pneumoniae, or S. aureus. Dr. Stout-Delgado’s research is currently funded by NIH R01 grants and is a co-Program Director of the Pulmonary and Critical Care Medicine T32 grant. 

Highlights

  1. 1
    American journal of respiratory cell and molecular biology · 2021
    HWHeather Winona Stout-Delgado
    PMID: 33625952PMCID: PMC8086037DOISenior author48 citations
  2. 2
    Redox biology · 2024
    DGDavid George ThomasHWHeather Winona Stout-Delgado
    PMID: 39197317PMCID: PMC11400614DOISenior author5 citations
  3. 3
    Cells · 2023
    HWHeather Winona Stout-Delgado
    PMID: 36831236PMCID: PMC9953875DOISenior author8 citations

Publications

39 publications

Funding

13 grantsView NIH portfolio on RePORTER ↗

Active

5 grants
  • KP
    Immunometabolic mediators of liver injury in influenza infection
    National Heart, Lung, and Blood Institute · 2026–2031
    K08HL188195-01
  • Co-I
    Developing Hyperpolarized Gas MRI signatures to detect and manage acute cellular rejection
    National Heart, Lung, and Blood Institute · 2026–2029 · via University of Virginia
    R01HL173369-03
  • MPI
    Multidisciplinary Approach Training in Respiratory Research
    National Heart, Lung, and Blood Institute · 2023–2028· 2 renewals
    T32HL134629-09
  • MPI
    Impact of Aging on Oxysterol Regulation of Alveolar Macrophage Function during S. pneumoniae
    National Institute on Aging · 2023–2028
    No publications yet
    R01MH133953-04
  • PI
    Impact of Aging on Oxysterol Regulation of Alveolar Macrophage Function during S. pneumoniae
    NIA · 2023–2028 · via NIH RePORTER
    R01AG079937-04
Completed grants (8)
  • KP
    Alveolar Macrophage Iron-induced Dysfunction in COPD Pathogenesis
    Parker B. Francis Foundation · 2022–2025
    PBFF 221418-01
  • PI
    Impact of Heightened UPR Activation on Inflammasome Responses to Influenza and Secondary Streptococcus pneumoniae Infection in Aged Lung
    National Institute on Aging · 2018–2024· 2 renewals
    R01AG056699-05S1
  • Co-I
    GLUT1-Dependent Glycolysis Regulates Age-Susceptible Lung Fibrosis
    National Heart, Lung, and Blood Institute · 2017–2023Career
    K08HL138285-02
  • PI
    Impact of Heightened ER Stress on NLRP3 Activation in Aged Lung During Infection
    National Institute on Aging · 2017–2023
    R01AG052530-05
  • Co-I
    Mitochondrial Iron Metabolism in Chronic Obstructive Pulmonary Disease
    National Heart, Lung, and Blood Institute · 2017–2020
    R00HL125899-03
  • KP
    GLUT1-Dependent Glycolysis Regulates Age-Related Lung Fibrogenesis
    American Lung Association, Incorporated · 2017–2018
    RG-512060
  • PI
    Aging with Chronic Viral Infections and the Impact on Innate Immune Responses
    NIA · 2011–2017 · via NIH RePORTER
    K01AG034999-06
  • PI
    Detection and Use of Novel Therapeutics to Stimulate NLRP3 Activity in the Elderly
    National Institute on Aging · 2014–2016
    R21AG044755-02

Honors & distinctions

4 honors
  • Distinguished Alumni, J. Wayne Streilen Award · UT Southwestern Medical Center · 2023
  • Member · Sigma Xi Honor Society · 2023
  • Member · American Association of Immunologists · 2007
  • Member · Golden Key National Honor Society · 2001

Clinical research

1 study

Active

1 study
  • PI
    PPIF-Mediated Regulation of Neutrophil Responses during Pneumonia
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)

Mentoring

20 menteesAll publications with mentees →
1 Postdoc · 19 other