Overview
I am the director of the Applied Bioinformatics Core Facility that specializes in providing data management and analysis support to large genomic centers and research groups. The core provides analytical capabilities to support and advance biomedical research with ample expertise in analyzing biological data from diverse types of experiments including, but not limited to, high-throughput genomic assays and single cell platforms.
We have extensive experience in building standardized workflows as well as customized, in-depth analyses with emphasis on thorough quality control and statistical rigor. We perform detailed computational analyses that are driven by specific biological questions defined by the investigators.
For more information visit the core website at abc.med.cornell.edu.
In my independent research group, we collaborate with stem cell and cancer biologists to study developmental processes and tumorigenesis. Our work applies and develops machine learning methods to model cellular transitions in response to environmental perturbations (e.g., the tumor microenvironment) or temporal processes (e.g., aging, differentiation, tumor progression). Specifically, we are interested in modeling cellular aging and its impact on neurodegeneration, as well as developing improved neurodifferentiation approaches for therapeutic applications. In cancer biology, we investigate how the immune microenvironment influences response to immunotherapy using single cell and spatial technologies, and we are developing computational approaches for comparing mouse tumor models with human tumors.
For more information see our lab research website betelab.med.cornell.edu
Beyond my research activities, I am heavily involved in education and teaching at WCM. I serve as co director of the Computational Biology & Medicine graduate program, overseeing student affairs and admissions as well as teach and co lead graduate courses.
Highlights
- 1
- 2Frontiers in aging neuroscience · 2026
- 3Cancer research · 2026
Publications
Funding
Active
7 grants- MPIT32GM132083-07Tri-Institutional PhD Program in Computational Biology & MedicineNIGMS · 2025–2030 · via NIH RePORTER
- Sub-PIR01AG054720-06A1Measuring and directing cellular age in cortical neurons and glial cells in models of Alzheimer's' diseaseNational Institute on Aging · 2017–2030 · via Memorial Sloan Kettering Cancer Center· 2 renewals
- Sub-PIR01AI173249-04Autoimmune Stem-like CD8 T cells in Type I DiabetesNational Institute of Allergy and Infectious Diseases · 2023–2028 · via Memorial Sloan Kettering Cancer Center
- Co-IR01AI170245-04Mechanisms of CTL Resistance in HIV ReservoirsNational Institute of Allergy and Infectious Diseases · 2022–2027
- Sub-PIR01NS118067-05Directing Fate, Subtype Identity And Survival In Human Pluripotent-Derived Midbrain Dopamine NeuronsNational Institute of Neurological Disorders and Stroke · 2021–2027 · via Memorial Sloan Kettering Cancer Center
- Sub-PIR01CA269733-04TOX-driven CD8 T cell differentiation and dysfunction in tumorsNational Cancer Institute · 2023–2026 · via Memorial Sloan Kettering Cancer Center
- Co-IUM1AI164565-01REACH: Research Enterprise to Advance a Cure for HIVNational Institute of Allergy and Infectious Diseases · 2021–2026
Completed grants (7)
- Co-IR56AI152764-01A1Defining & Characterizing Novel Mechanisms by which HIV-infected Primary CD4+ T-cells Intrinsically Resist Elimination by CTLNational Institute of Allergy and Infectious Diseases · 2020–2022
- Co-IR25MD011713-04CUNY-WCM Big Data Training Program in Biomedical Informatics (BD2BMI)National Institute on Minority Health and Health Disparities · 2017–2021 · via Research Foundation of CUNY
- KP110031-67-RGRLIntegrating Transcriptomic and Proviral Integration Site Data-Sets to Define Mechanisms of 'CTL Resistance' in ReservoirAmerican Foundation for AIDS Research (amfAR) · 2020–2021
- PI2013379Linking Histone Demethylation With RNA: Systematic Mapping of KDM4D-RNA InteractionsUnited States Israel Binational Science Foundation · 2014–2019
- Co-II8-A8-132The Impact of the Gastric Microbiome on Gastric Cancer DevelopmentStarr Cancer Consortium · 2015–2018
- PITSCI 2016-026A Novel Mouse Model to Study miRNA Function in Embryonic and Adult Stem CellsTri-Institutional Stem Cell Initiative (Weill Cornell) · 2016–2018
- Sub-PIR21MH096258-02Molecular Substrates of Translation at the SynapseNational Institute of Mental Health · 2012–2014 · via Scripps Research Institute
News mentions
- Rare Stem T Cells May Hold the Key to Fighting Chronic DiseasesJuly 1, 2026
A small subset of T cells, called stem T cells, are responsible for making new T cells and for continuously replenishing them in chronic disease, according to a team of scientists from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center.
- Losing Key Type of Pancreatic Cell May Contribute to DiabetesMarch 16, 2023
Multiple types of beta cells produce insulin in the pancreas, helping to balance blood sugar levels. Losing a particularly productive type of beta cell may contribute to the development of diabetes.
Mentoring
- FCFayzan ChaudhryTri-I Program in Computational Biology & Medicine (PhD) · Class of 2026
- JRJonathan RubTri-I Program in Computational Biology & Medicine (PhD) · Class of 2025
- MMMassoud MaherTri-I Program in Computational Biology & Medicine (PhD) · Class of 2021