Overview
Claire Vanpouille-Box, PhD, is an Assistant Professor in the Department of Radiation Oncology at Weill Cornell Medicine and Director of the Radiation Therapy Preclinical Core (RTPC).
Her research program investigates how radiation therapy influences tumor immunogenicity and how metabolic adaptation, particularly lipid metabolism, enables aggressive brain tumors to resist treatment and evade immune attack. She received her PhD from the University of Angers in France and completed postdoctoral training at NYU School of Medicine and Weill Cornell Medicine. Her work has helped define key mechanisms of radiation-induced anti-tumor immunity, including the role of TGF-β as a suppressor of immune responses and the importance of cancer cell-intrinsic type I interferon signaling in the abscopal effect.
She has been recognized with honors including the Marie Curie Award from the Radiation Research Society, the AACR–Susan G. Komen Scholar-in-Training Award, and the St. Baldrick’s Foundation Scholar Award.
She also serves in editorial roles for several journals in the field, including International Journal of Radiation Oncology - Biology - Physics, Radiation Research, and Journal of Translational Medicine.
Highlights
- 1Cancer letters · 2023
- 2Cancer letters · 2025
- 3Nature reviews. Immunology · 2024
Publications
Funding
Active
8 grants- KPPCT 38590Targeting fatty acid synthesis to restore anti-tumor immunity against irradiated glioblastomaPew Charitable Trusts · 2025–2029
- PIR01NS131945-04Fatty acid metabolic regulation of anti-tumor immunity against irradiated glioblastomaNational Institute of Neurological Disorders and Stroke · 2023–2028
- Co-IR37CA278671-01Customized nanofibers with preferential lung-targeting properties for treating metastatic pulmonary tumorsNational Cancer Institute · 2023–2027
- MPIU54CA274291-01Dynamics of Immune Response in Irradiated Rectal CancerNational Cancer Institute · 2022–2027
- Co-ISRA 224196-01Investigating PK modulation in targeted radiotherapyRatio Therapeutics, LLC · 2022–2026Contract
- PIR21CA280787-02Role of FAP-positive cells in immune response to irradiated glioblastomaNational Cancer Institute · 2023–2026
- PIUKF 244480-01Regulation of myeloid cells by fatty acid metabolism in irradiated glioblastomaUncle Kory Foundation · 2025–2025
- KPBTC 224874-01Role of CD36 in immune response to irradiated glioblastomaThe Brain Tumor Charity · 2023–2025
Completed grants (9)
- PIUKF 234339-01Regulation of myeloid cells by fatty acid metabolism in irradiated glioblastomaUncle Kory Foundation · 2024–2024
- PISBF 222633-02Targeting CAFs to sensitize irradiated pHGG to EGFR blockadeSt. Baldrick's Foundation · 2022–2024
- KPS10OD032317-01Hypoxic incubator for physiological cell culture researchOffice of the Director, NIH · 2022–2023
- KPSIC 224099-01Targeting FASN to sensitize irradiated glioblastoma to immunotherapySociety For Immunotherapy of Cancer · 2022–2023
- PISSI 224537-01Targeting cancer-associated fibroblasts in irradiated pediatric brain tumorsStachestrong Inc. · 2022–2023
- PIUKF 221422-01Targeting CAFs to sensitize irradiated glioblastoma to PD-1 blockade.Uncle Kory Foundation · 2021–2022
- KPR01CA201246-05Cancer Cell Intrinsic Interferon-I Pathway Activation by Fractionated RadiationNational Cancer Institute · 2016–2022
- PIBC 193359-01Evaluation of targeted alpha-radiation therapy to induce anti-tumor immune responses in mouse models of glioblastoma.B*CURED · 2019–2020
- PIRRF 193737-01Evaluation of targeted alpha-radiation therapy to induce anti-tumor immune responses in a GL261 glioma model.Radiation Research Foundation · 2019–2020
Honors & distinctions
- Marie Curie Award · Radiation Research Society
- Member · Society for Immunotherapy of Cancer (SITC)
- Member · American Society for Radiation Oncology (ASTRO)
- Member · Radiation Research Society (RRS)
- Member · American Association for Cancer Research (AACR)
- St. Baldrick’s Foundation Scholar · St. Baldrick's Foundation
Available technologies
- FASN Inhibition Overcomes Radiation Resistance and Potentiates Anti-PD-1 Therapy in Glioblastoma11200Application filedPoC DataPMID 37499741