Charles M. Rice, PhD

Highlights

1
Proceedings of the National Academy of Sciences of the United States of America · 2026
GBGeorgia BrousseauYPYpe P. de Jong CMCharles M. Rice
PMID: 42012961PMCID: PMC13123901DOISenior author3 citations

Publications

477

Funding

39 View NIH portfolio on RePORTER ↗

Active

10 grants

MPI
Elucidating the host and viral determinants of treatment response in chronic hepatitis B
NIAID · 2026–2031 · via NIH RePORTER
R01AI190067-01A1
MPI
Launching HBV with RNA to assess antiviral resistance and explore fundamental aspects of virus-host biology
NIAID · 2020–2030 · via NIH RePORTER
R01AI150275-07
MPI
Breaching the species barrier: Towards an immunocompetent HBV-susceptible mouse model
NIAID · 2024–2029 · via NIH RePORTER
R01AI183884-03
MPI
Metropolitan AntiViral Drug Accelerator (Project 3)
NIAID · 2022–2028 · via NIH RePORTER
U19AI171401-02
PI
Employing viruses to unravel the functional significance of the m5C epitranscriptome
NIAID · 2023–2028 · via NIH RePORTER
R01AI175382-04
PI
TMEM41B: a pan-flavivirus and pan-coronavirus host factor with antiviral potential
NIAID · 2022–2027 · via NIH RePORTER
R01AI169015-05
PI
Unraveling yellow fever 17D vaccine attenuation: The role of type I interferon and innate immunity
NIAID · 2016–2027 · via NIH RePORTER
R01AI124690-10
PI
Tracking SARS-CoV-2 one molecule at a time: Spatiotemporal investigation of coronavirus replication dynamics and host response in single cells in vitro and in vivo
NIAID · 2022–2027 · via NIH RePORTER
R01AI161444-05
MPI
A clear view of encephalitis: a single cell approach to determine the basis of flaviviral pathogenesis in the central nervous system
NIAID · 2022–2026 · via NIH RePORTER
R01AI158676-05
MPI
Scientific Core: BSL3 Virology and Animal Models
NIAID · 2022–2025 · via NIH RePORTER
P01AI165075-01S1

Completed grants (29)

PI
A renewable and genetically tractable human stem cell-derived multicellular platform for the study of fibrotic liver diseases
NIDDK · 2021–2025 · via NIH RePORTER
R01DK125100-04
PI
Elucidating the mechanism by which ADAR1 prevents autoimmunity against self RNA
NIAID · 2023–2025 · via NIH RePORTER
R21AI171880-02
MPI
In search of an HBV cure: novel model systems and targets
NIAID · 2019–2024 · via NIH RePORTER
R01AI143295-05
PI
Identification of host factors required by the tick-borne Powassan virus
NIAID · 2020–2023 · via NIH RePORTER
R21AI153927-02
PI
Virology Core
NIAID · 2018–2023 · via NIH RePORTER
P01AI138938-05
PI
Defining therapeutic drug targets for SARS-CoV-2-specific and pan-coronavirus inhibition
NIAID · 2021–2023 · via NIH RePORTER
R21AI161212-01
PI
Analysis of immunity, viral adaptation and pathogenesis in a new mouse model of HCV-related rodent hepacivirus infection
NIAID · 2017–2023 · via NIH RePORTER
R01AI131688-05
PI
Type I interferon-stimulated genes and the antiviral immune response
NIAID · 2011–2022 · via NIH RePORTER
R01AI091707-10S1
PI
A systematic analysis of small RNA interactions during RNA virus infections
NIAID · 2015–2021 · via NIH RePORTER
R01AI116943-05
PI
HEP DART 2019: Frontiers in Drug Development for Hepatology
NIAID · 2019–2020 · via NIH RePORTER
R13AI150088-01
PI
Host factors in innate immunity and retroelement control
NIAID · 2017–2019 · via NIH RePORTER
R21AI134041-02
PI
Hepatitis C antivirals: Mechanism of action, combination efficacy and resistance
NIAID · 2012–2017 · via NIH RePORTER
R01AI099284-05
PI
Identification and characterization of cellular factors involved in HCV entry
NIAID · 2006–2017 · via NIH RePORTER
R01AI072613-10
PI
Transmitted/Founder HCV clones as targets for treatment and eradication.
NIAID · 2013–2016 · via NIH RePORTER
R21AI106000-02
PI
Structure and function of the HCV RNA replicase
NCI · 1992–2016 · via NIH RePORTER
R01CA057973-20
PI
Modeling human hepatotropic infections in complex tissue organoids
NIDDK · 2009–2015 · via NIH RePORTER
R01DK085713-05
PI
Simianizing hepatitis C: Defining the species-tropism of a hepatotropic virus
NIAID · 2010–2015 · via NIH RePORTER
R01AI090055-05
MPI
Identification of interferon effectors that inhibit RNA virus replication
NIAID · 2011–2015 · via NIH RePORTER
U54AI057158-10
PI
Role of HCV p7 and NS2 in infectious virus production
NIAID · 2008–2013 · via NIH RePORTER
R01AI075099-05
MPI
HOST FACTORS ASSOCIATED WITH THE SINDBIS VIRUS RNA-DEPENDENT RNA POLYMERASE
NCRR · 2004–2012 · via NIH RePORTER
P41RR000862-38
PI
An inbred mouse model for HCV infection, immunity andpathogenesis
NIDDK · 2009–2011 · via NIH RePORTER
RC1DK087193-02
PI
Administrative Core
NIAID · 1996–2010 · via NIH RePORTER
U19AI040034-15
PI
FLAVIVIRUS CAPSID ASSEMBLY AND VIRUS ENTRY
NCRR · 2004–2007 · via NIH RePORTER
P41RR004050-18
PI
MOLECULAR GENETICS OF SINDBIS VIRUS REPLICATION
NIAID · 1987–2007 · via NIH RePORTER
R37AI024134-18
PI
Conference--Drug development for Viral Hepatitis
NIAID · 2005–2006 · via NIH RePORTER
R13AI066875-01
PI
Viruses and Cells Gordon Conference
NIAID · 2005–2006 · via NIH RePORTER
R13AI065104-01
PI
Small Molecules as Research Tools for HCV Biology
NIDDK · 2003–2006 · via NIH RePORTER
R21DK063911-02
MPI
HCV PATHOGENESIS AND DENDRITIC CELL IMMUNOBIOLOGY
NCRR · 2003–2005 · via NIH RePORTER
No publications yet
M01RR000102-41
PI
IMMUNOTHERAPY PROTECTION & VACCINES FOR HEPATITIS C
NCI · 1999–2005 · via NIH RePORTER
R01CA085883-06

Honors & distinctions

2

Nobel Prize in Physiology or Medicine · Nobel Foundation · 2020
Pew Scholar in the Biomedical Sciences · Pew Charitable Trusts · 1986

Mentoring

3 All publications with mentees →