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ScholarsBetaWeill Cornell Medicine

Overview

Her research experience has been in pediatric neuro-critical care, delirium in seriously ill children, and in the development of a genetic vaccine against Respiratory Syncytial Virus. Dr. Traube's clinical interest and area of expertise is in the diagnosis and management of critically ill children.

CURRENT RESEARCH PROJECTS

Detecting Pediatric Delirium: Validation of a Rapid, Observational Assessment Tool (CAP-D): Delirium in critically ill children represents acute brain dysfunction, with short- and long-term health implications. There is an emerging literature suggesting that this is a common, serious, and under-diagnosed problem in seriously ill children. Evidence-based assessments of outcomes and interventions for pediatric delirium are lacking, largely due to the absence of a simple and reliable screening tool.

My research partners and I have developed a novel screening tool for the detection of delirium in this population, and have completed a pilot study confirming its feasibility, and suggesting a prevalence of >25% in our subjects. We are in midst of a validation study of the Cornell Assessment for Pediatric Delirium (CAP-D) in critically ill pediatric patients, which will allow for rapid and accurate identification of delirious children, and facilitate appropriate interventions.

Prevalence of Acute Critical Neurologic Disease in Children: A Global Epidemiological Assessment (PANGEA): This is a national study to describe the epidemiology and gross outcomes of acute critical neurologic disease in children.

Critical Pertussis in US Children: Severe Morbidity, Sequelae, and Mortality: A Prospective Cohort Study: This is an NIH-sponsored, multi-institutional study to describe the long-term outcome after pertussis infection.

Pediatric Traumatic Brain Injury Consortium: Hypothermia: This is a multi-institutional, international, NIH-sponsored, international Phase III randomized controlled clinical trial to evaluate the effect of moderate hypothermia as compared to normothermia following severe traumatic brain injury in children. Status: Closed to enrollment; follow-up ongoing

Highlights

  1. 1
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2020
    GHGabrielle H. SilverSSSusan SamuelsAHAnna Halperin RosenMWMeredith Weiss+2 more →CTChani Traube
    PMID: 32106184DOISenior author39 citations
  2. 2
    Critical care medicine · 2020
    LMLinda M GerberCTChani Traube
    PMID: 33031144PMCID: PMC8195312DOISenior author66 citations
  3. 3
    Hospital pediatrics · 2021
    CTChani Traube
    PMID: 34711646DOISenior author24 citations

Publications

100 publications

Funding

6 grantsView NIH portfolio on RePORTER ↗

Active

4 grants
  • MPI
    Empowering Parents of Critically Ill Children: A Multi-Site Evaluation of the EMPOWER-PICU Intervention
    NINR · 2026–2031 · via NIH RePORTER
    R01NR022612-01A1
  • Co-I
    Behavioral and Psychosocial Effects on Study Outcomes in End-Stage Cancer Treatment (BEST End-Stage Cancer Study)
    National Cancer Institute · 2022–2029
    R35CA197730-08
  • PI
    Optimizing Pain Treatment In Children On Mechanical ventilation (OPTICOM)
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2024–2027
    U01HD116260-03
  • PI
    Delirium in Children Undergoing Hematopoietic Stem Cell Transplants
    National Cancer Institute · 2020–2026
    R01CA244500-05
Completed grants (2)
  • Sub-PI
    Pharmacokinetics of sedatives - Understanding a modifiable risk factor for pediatric delirium
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2019–2024 · via Children's Research Institute
    R01HD099284-04
  • Sub-PI
    Critical Pertussis in U.S. Children: Severe Morbidity, Sequelae, and Mortality: A Prospective Cohort Study
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2010–2014 · via University of Utah
    U01HD049934-09 EW

Clinical research

6 studies

Active

3 studies
  • PI
    Dexmedetomidine Use in Mechanically Ventilated Children: A Longitudinal Study
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)
  • PI
    Optimizing Pain Treatment in Children On Mechanical Ventilation
    PHASE3 · Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2025)
    Mechanical Ventilation; Pediatric Acute Respiratory Failure; Analgesics, Opioid; Sedation and Analgesia
    NCT06994442
  • PI
    Child Life after PICU-2-BRANYplus transfer
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2022)
Completed & closed trials (3)
  • PI
    CAP-3: Parenting after PICU
    Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2024)
  • PI
    Pharmacokinetics of Sedatives? Understanding a modifiable risk factor for pediatric delirium
    Children's National Hospital · CLOSED TO ACCRUAL (as of 2024)
  • PI
    Delirium in Children Undergoing Stem Cell Transplantation: Epidemiology and Outcomes
    Weill Medical College of Cornell University · CLOSED TO ACCRUAL (as of 2024)

News mentions

1 mentionView all WCM news ↗
  • Weill Cornell Medicine Receives Grant to Fund Pain Control Research for Critically Ill Children
    October 31, 2024

    Dr. Chani Traube, the Gerald M. Loughlin, MD Professor of Pediatrics at Weill Cornell Medicine, has been awarded a $3.4 million grant, with the possibility of extending to a total of $17 million over five years, from the National Institutes of Health, for a large-scale clinical trial called Optimizing Pain Treatment in Children on Mechanical ventilation (OPTICOM).

Mentoring

4 menteesAll publications with mentees →