Overview
From Stem Cells to Organogenesis
Learn more about the Evans Laboratory in this video.
Highlights
- 1Development (Cambridge, England) · 2024
- 2
- 3Cell reports · 2021
Publications
Funding
Active
8 grants- Co-IR01HL188510-01Endothelin-1 inhibits cardiomyocyte proliferation and heart regenerationNational Heart, Lung, and Blood Institute · 2026–2030
- Co-IR01HL155607-06A1Mechanisms controlling epicardial-dependent promotion of heart regeneration in zebrafish.National Heart, Lung, and Blood Institute · 2026–2030
- Co-IR01HL177538-01A1Mechanistic re-evaluation of fibroblast growth factor homologous factors in the heartNational Heart, Lung, and Blood Institute · 2025–2029
- MPIR01HL186602-01Dissecting the molecular pathways controlling human pacemaker developmentNational Heart, Lung, and Blood Institute · 2026–2028
- PIR01HD111256-05Regulation of DNA methylation by TETs and QSER1Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2022–2027
- KPCCFA #1068936Analysis of biologic signatures in Crohn's patients undergoing surgeryCrohn's and Colitis Foundation of America · 2023–2026
- MPIR01HD101452-05Negative feedback regulation of growth factor signaling in adult spermatogonial stem cellsEunice Kennedy Shriver National Institute of Child Health and Human Development · 2021–2026· 2 renewals
- Sub-PIR01HL157157-04Genetic modifiers of congenital heart disease in 22q11.2 deletion syndromeNational Heart, Lung, and Blood Institute · 2022–2026 · via Yeshiva University
Completed grants (30)
- PITri-Sci #2023-006Discovery of functional enhancers in human cardiac and pancreatic developmentTri-Institutional Stem Cell Initiative (Weill Cornell) · 2023–2025
- Co-IR01GM129380-01H3.3-mediated epigenetic regulation of developmental bivalent genes for reprogramming and differentiationNational Institute of General Medical Sciences · 2018–2025
- MPIR21HD107212-02Methods for detection of dynamic intracellular signals in single adult spermatogonial stem cellsEunice Kennedy Shriver National Institute of Child Health and Human Development · 2023–2025
- PIR35HL135778-07A Gata456 Pipeline of DiscoveryNational Heart, Lung, and Blood Institute · 2017–2023
- PIDOH01-C32558GG-3450000Weill Cornell Training Program in Stem Cell Biology and Regenerative MedicineNew York State Stem Cell Science (NYSTEM) · 2018–2023
- PISRA 214834-01Research Support AgreementThe Feinstein Institute for Medical Research · 2021–2023Contract
- PITri-SCI #2021-005Defining the roles of QSER1, a novel regulator of DNA methylation, in stem cell differentiation and developmentTri-Institutional Stem Cell Initiative (Weill Cornell) · 2021–2023
- KPF32HL152575-02Defining the downstream genetic networks regulated by GATA6 during human cardiogenesis using iPSC and hESC modelsNational Heart, Lung, and Blood Institute · 2020–2023Fellowship
- PICU 222545-01Engineering Ventricular Maturation for Congenital and Post-Infarct RegenerationCornell University - Ithaca · 2022–2022
- PIBP 220583-01Evans BP Alliance AgreementDaedalus Fund for Innovation (Weill Cornell) · 2021–2022BioPharma Alliance
- MPIR01DK119667-02S1Metallothionein 1E as a Central Regulator of Human Pancreatic Beta Cell Function and SurvivalNational Institute of Diabetes and Digestive and Kidney Diseases · 2020–2022
- Sub-PIC32593GGNovel Regulators of Endoderm DifferentiationNew York State Department of Health · 2018–2021 · via Sloan-Kettering Institute for Cancer Research
- PIDOH01-C32591GG-3450000Deriving Functional Cardiac Pacemaker Cells from Human Embryonic Stem CellsNew York State Stem Cell Science (NYSTEM) · 2018–2021
- Co-IBMGF INV-018723COVID-19 CTA: Compound screening using organoid modelBill & Melinda Gates Foundation · 2020–2021
- Co-I18CSA34080171Identify Pathogenic Genetic Variants Associated with Anthracycline-related CardiotoxicityAmerican Heart Association · 2018–2021
- Co-IC0 30160Vascular Niche Platform to Expand Hematopoietic Stem and Progenitor Cells Engineered to Cure Sickle Cell DiseaseNew York State Stem Cell Science (NYSTEM) · 2015–2020
- PIW81XWH-17-1-0661Regulation of Cardiogenesis by GATA Transcription FactorsU.S. Department of Defense · 2017–2020
- PI2014-009Molecular Control of Primitive Versus Definitive Endoderm Fates From Stem CellsTri-Institutional Stem Cell Initiative (Weill Cornell) · 2014–2019
- PISA 184568-01Organic Synthesis Core Facility - Core Services Use AgreementSloan-Kettering Institute for Cancer Research · 2018–2019Contract
- Co-IDFI 191231-01A novel small molecule that directly promotes and accelerates osteoblast differentiation and mineralizationDaedalus Fund for Innovation (Weill Cornell) · 2018–2019
- PI2016-032TET-Dependent Epigenetic Mechanisms Controlling Human Embryonic Stem Cell DifferentiationTri-Institutional Stem Cell Initiative (Weill Cornell) · 2016–2019
- PI2016-004Discovery of Genetic and Environmental Modifiers of Diabetes-Spectrum Diseases Associated With GATA6 Haploinsufficiency Using Novel hPSC PlatformsTri-Institutional Stem Cell Initiative (Weill Cornell) · 2016–2018
- PIC029156A Shared Facility for the Derivation, Validation, and Distribution of Stem Cells for Disease ModelingNew York State Stem Cell Science (NYSTEM) · 2014–2018
- PI2014-010Epigenetic Regulation of Hematopoietic Stem Cells by 5-HydroxymethylcytosineTri-Institutional Stem Cell Initiative (Weill Cornell) · 2014–2017
- PIR37HL056182-20Regulation of Embryonic Erythropoiesis by BMP SignalingNational Heart, Lung, and Blood Institute · 2012–2016
- PIR01HL111400-04A Molecular Pathway Controlling Cardiomyocyte SpecificationNational Heart, Lung, and Blood Institute · 2011–2016
- KPR01HL089934-08Sphingosine 1-Phosphate Receptors in Vascular Homeostasis and PathologyNational Heart, Lung, and Blood Institute · 2014–2016
- MPIT32HL083824-05Multidisciplinary Vascular Surgery Research Training ProgramNHLBI · 2006–2013 · via NIH RePORTER
- PIR01HL056182-12Regulation of Embryonic Erythropoiesis by BMP SignalingNHLBI · 1997–2012 · via NIH RePORTER
Honors & distinctions
- Searle Scholars Program · Searle Scholars Program · 1991
Clinical research
Active
1 study- PIA Repository to Enable Modeling of Human Cardiovascular DiseaseWeill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)
Available technologies
News mentions
- Scientists Use Organoid Model to Identify Potential New Pancreatic Cancer TreatmentDecember 26, 2023
A drug screening system that models cancers using lab-grown tissues called organoids has helped uncover a promising target for future pancreatic cancer treatments, according to a new study from researchers at Weill Cornell Medicine.
- Study Identifies Human Genes Enabling SARS-CoV-2 InfectionMarch 13, 2023
The activity of a gene called CIART is a key factor in the establishment of the viral infection that causes COVID-19.
- Are COVID-19-Linked Arrhythmias Caused by Viral Damage to the Heart’s Pacemaker Cells?April 1, 2022
The SARS-CoV-2 virus can infect specialized pacemaker cells that maintain the heart’s rhythmic beat, setting off a self-destruction process within the cells, according to a preclinical study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian and NYU Grossman School of Medicine.
- Study Reveals a Cause of Heart Damage in COVID-19 and Potential TreatmentsApril 23, 2021
The heart damage seen in many severely ill COVID-19 patients results in part from infection-activated immune cells called macrophages, which infiltrate the heart and secrete cell-damaging chemicals, according to a study co-led by researchers at Weill Cornell Medicine, NewYork-Presbyterian, Icahn School of Medicine at Mount Sinai and Columbia University Irving Medical Center.
- Pluripotent Stem Cells Shed Light on How COVID-19 Infects the Pancreas and Liver and Its Relationship with DiabetesJuly 23, 2020
The study of human pluripotent stem cells, which can develop into any cell type in the body, is providing Weill Cornell Medicine and NewYork-Presbyterian investigators with new insights into the virus that causes COVID-19 and how it may infect organs such as the pancreas and liver.
Show 1 more mention
- Weill Cornell Medicine Tackles COVID-19May 7, 2020
Physicians and scientists at Weill Cornell Medicine and NewYork-Presbyterian have rapidly mobilized to confront the COVID-19 pandemic, focusing a broad spectrum of expertise on the critical issues the disease is posing to healthcare workers and public health officials.
Mentoring
MD · 1
- YJYujin JooMD mentee · Class of 2020
PhD · 8
- NWNicholas WalkerPhysiology, Biophysics & Systems Biology (PhD) · Class of 2026
- JSJessica SamCell & Developmental Biology (PhD) · Class of 2024
- RRRuhina RafiqCell & Developmental Biology (PhD) · Class of 2020
- HLHeejin LeeCell & Developmental Biology (PhD) · Class of 2019
- SPSuveg PandeyCell & Developmental Biology (PhD) · Class of 2019
- EMEmily MercerPharmacology (PhD) · Class of 2017
- SLSusanna LiuCell & Developmental Biology (PhD) · Class of 2016
- RWRebecca WuCell & Developmental Biology (PhD)
Postdoc · 2
- ZSZohreh Sadat BadieyanPostdoc mentee · 2021–2021
External relationships
Advisory/Scientific Board Member
OncoBeat, LLC
Other
OncoBeat, LLC