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Overview

From Stem Cells to Organogenesis

>For more information, please visit our laboratory website:  http://toddevanslab.net

Learn more about the Evans Laboratory in this 
video.

Highlights

  1. 1
    Development (Cambridge, England) · 2024
    PMID: 39133135PMCID: PMC11423812DOISenior author3 citations
  2. 2
    eLife · 2025
    PMID: 40080060PMCID: PMC11906159DOISenior author
  3. 3
    Cell reports · 2021
    PMID: 34879277PMCID: PMC11229417DOISenior author33 citations

Publications

202 publications

Active

8 grants
  • Co-I
    Endothelin-1 inhibits cardiomyocyte proliferation and heart regeneration
    National Heart, Lung, and Blood Institute · 2026–2030
    R01HL188510-01
  • Co-I
    Mechanisms controlling epicardial-dependent promotion of heart regeneration in zebrafish.
    National Heart, Lung, and Blood Institute · 2026–2030
    R01HL155607-06A1
  • Co-I
    Mechanistic re-evaluation of fibroblast growth factor homologous factors in the heart
    National Heart, Lung, and Blood Institute · 2025–2029
    R01HL177538-01A1
  • MPI
    Dissecting the molecular pathways controlling human pacemaker development
    National Heart, Lung, and Blood Institute · 2026–2028
    R01HL186602-01
  • PI
    Regulation of DNA methylation by TETs and QSER1
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2022–2027
    R01HD111256-05
  • KP
    Analysis of biologic signatures in Crohn's patients undergoing surgery
    Crohn's and Colitis Foundation of America · 2023–2026
    CCFA #1068936
  • MPI
    Negative feedback regulation of growth factor signaling in adult spermatogonial stem cells
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021–2026· 2 renewals
    R01HD101452-05
  • Sub-PI
    Genetic modifiers of congenital heart disease in 22q11.2 deletion syndrome
    National Heart, Lung, and Blood Institute · 2022–2026 · via Yeshiva University
    R01HL157157-04
Completed grants (30)
  • PI
    Discovery of functional enhancers in human cardiac and pancreatic development
    Tri-Institutional Stem Cell Initiative (Weill Cornell) · 2023–2025
    Tri-Sci #2023-006
  • Co-I
    H3.3-mediated epigenetic regulation of developmental bivalent genes for reprogramming and differentiation
    National Institute of General Medical Sciences · 2018–2025
    R01GM129380-01
  • MPI
    Methods for detection of dynamic intracellular signals in single adult spermatogonial stem cells
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023–2025
    R21HD107212-02
  • PI
    A Gata456 Pipeline of Discovery
    National Heart, Lung, and Blood Institute · 2017–2023
    R35HL135778-07
  • PI
    Weill Cornell Training Program in Stem Cell Biology and Regenerative Medicine
    New York State Stem Cell Science (NYSTEM) · 2018–2023
    DOH01-C32558GG-3450000
  • PI
    Research Support Agreement
    The Feinstein Institute for Medical Research · 2021–2023Contract
    SRA 214834-01
  • PI
    Defining the roles of QSER1, a novel regulator of DNA methylation, in stem cell differentiation and development
    Tri-Institutional Stem Cell Initiative (Weill Cornell) · 2021–2023
    Tri-SCI #2021-005
  • KP
    Defining the downstream genetic networks regulated by GATA6 during human cardiogenesis using iPSC and hESC models
    National Heart, Lung, and Blood Institute · 2020–2023Fellowship
    F32HL152575-02
  • PI
    Engineering Ventricular Maturation for Congenital and Post-Infarct Regeneration
    Cornell University - Ithaca · 2022–2022
    CU 222545-01
  • PI
    Evans BP Alliance Agreement
    Daedalus Fund for Innovation (Weill Cornell) · 2021–2022BioPharma Alliance
    BP 220583-01
  • MPI
    Metallothionein 1E as a Central Regulator of Human Pancreatic Beta Cell Function and Survival
    National Institute of Diabetes and Digestive and Kidney Diseases · 2020–2022
    R01DK119667-02S1
  • Sub-PI
    Novel Regulators of Endoderm Differentiation
    New York State Department of Health · 2018–2021 · via Sloan-Kettering Institute for Cancer Research
    C32593GG
  • PI
    Deriving Functional Cardiac Pacemaker Cells from Human Embryonic Stem Cells
    New York State Stem Cell Science (NYSTEM) · 2018–2021
    DOH01-C32591GG-3450000
  • Co-I
    COVID-19 CTA: Compound screening using organoid model
    Bill & Melinda Gates Foundation · 2020–2021
    BMGF INV-018723
  • Co-I
    Identify Pathogenic Genetic Variants Associated with Anthracycline-related Cardiotoxicity
    American Heart Association · 2018–2021
    18CSA34080171
  • Co-I
    Vascular Niche Platform to Expand Hematopoietic Stem and Progenitor Cells Engineered to Cure Sickle Cell Disease
    New York State Stem Cell Science (NYSTEM) · 2015–2020
    C0 30160
  • PI
    Regulation of Cardiogenesis by GATA Transcription Factors
    U.S. Department of Defense · 2017–2020
    W81XWH-17-1-0661
  • PI
    Molecular Control of Primitive Versus Definitive Endoderm Fates From Stem Cells
    Tri-Institutional Stem Cell Initiative (Weill Cornell) · 2014–2019
    2014-009
  • PI
    Organic Synthesis Core Facility - Core Services Use Agreement
    Sloan-Kettering Institute for Cancer Research · 2018–2019Contract
    SA 184568-01
  • Co-I
    A novel small molecule that directly promotes and accelerates osteoblast differentiation and mineralization
    Daedalus Fund for Innovation (Weill Cornell) · 2018–2019
    DFI 191231-01
  • PI
    TET-Dependent Epigenetic Mechanisms Controlling Human Embryonic Stem Cell Differentiation
    Tri-Institutional Stem Cell Initiative (Weill Cornell) · 2016–2019
    2016-032
  • PI
    Discovery of Genetic and Environmental Modifiers of Diabetes-Spectrum Diseases Associated With GATA6 Haploinsufficiency Using Novel hPSC Platforms
    Tri-Institutional Stem Cell Initiative (Weill Cornell) · 2016–2018
    2016-004
  • PI
    A Shared Facility for the Derivation, Validation, and Distribution of Stem Cells for Disease Modeling
    New York State Stem Cell Science (NYSTEM) · 2014–2018
    C029156
  • PI
    Epigenetic Regulation of Hematopoietic Stem Cells by 5-Hydroxymethylcytosine
    Tri-Institutional Stem Cell Initiative (Weill Cornell) · 2014–2017
    2014-010
  • PI
    Regulation of Embryonic Erythropoiesis by BMP Signaling
    National Heart, Lung, and Blood Institute · 2012–2016
    R37HL056182-20
  • PI
    A Molecular Pathway Controlling Cardiomyocyte Specification
    National Heart, Lung, and Blood Institute · 2011–2016
    R01HL111400-04
  • KP
    Sphingosine 1-Phosphate Receptors in Vascular Homeostasis and Pathology
    National Heart, Lung, and Blood Institute · 2014–2016
    R01HL089934-08
  • MPI
    Multidisciplinary Vascular Surgery Research Training Program
    NHLBI · 2006–2013 · via NIH RePORTER
    T32HL083824-05
  • PI
    Regulation of Embryonic Erythropoiesis by BMP Signaling
    NHLBI · 1997–2012 · via NIH RePORTER
    R01HL056182-12
  • PI
    Function of GATA Factors in Cardiogenesis
    NHLBI · 2000–2010 · via NIH RePORTER
    R01HL064282-10

Honors & distinctions

1 honor
  • Searle Scholars Program · Searle Scholars Program · 1991

Clinical research

1 study

Active

1 study
  • PI
    A Repository to Enable Modeling of Human Cardiovascular Disease
    Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2026)

Available technologies

News mentions

Show 1 more mention
  • Weill Cornell Medicine Tackles COVID-19
    May 7, 2020

    Physicians and scientists at Weill Cornell Medicine and NewYork-Presbyterian have rapidly mobilized to confront the COVID-19 pandemic, focusing a broad spectrum of expertise on the critical issues the disease is posing to healthcare workers and public health officials.

1 MD student · 8 PhD students · 2 Postdocs

MD · 1

  • YJ
    Yujin Joo
    MD mentee · Class of 2020

PhD · 8

External relationships

Advisory/Scientific Board Member

OncoBeat, LLC

Other

OncoBeat, LLC