TerminatedInterventional · Phase 4NCT06578728 ↗Intralesional Methotrexate Injections for the Treatment of Nail Psoriasis: an Intra-subject Randomized Controlled TrialShari LipnerPIInterventionDrug: Methotrexate · Drug: Triamcinolone Acetonide 10mg/mL · Drug: SalineDatesSep 2025 – Jun 2026
CompletedInterventional · Phase 3NCT06584916 ↗A Phase 3b, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Orforglipron Once Daily Versus Placebo for Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related ComorbiditiesAlpana P. ShuklaPIInterventionDrug: Orforglipron · Drug: PlaceboDatesSep 2024 – Nov 2025SponsorEli Lilly and CompanyObesityOverweight
TerminatedInterventional · Phase 2NCT06585150 ↗A Phase 2 Randomized, Placebo-controlled Study of the Safety and Efficacy of Obeldesivir to Treat Nonhospitalized Adults With Acute Respiratory Syncytial Virus (RSV) InfectionCatherine Butkus SmallPIInterventionDrug: Obeldesivir · Drug: Obeldesivir PlaceboDatesOct 2024 – May 2025· Results postedSponsorGilead Sciences, Inc.RSV Infection
TerminatedInterventional · Not applicableNCT06646939 ↗Comparison of Community Reintegration Interventions Relative to the Institution of a Simulated Environment in Inpatient Rehabilitation and Pilot Study of the Impact of Simulated Environment on Functional OutcomesNasim ChowdhuryPIInterventionBehavioral: PT and OT with a simulated environmentDatesJul 2023 – Dec 2025SponsorWeill Medical College of Cornell UniversitySimulated Environments for Community Reintegration
CompletedInterventional · Not applicableNCT06664788 ↗A Prospective, Multicenter, Randomized Clinical Investigation Evaluating the Safety and Efficacy of ETHIZIA™ Versus SURGICEL® Original in Controlling Minimal, Mild, or Moderate Soft Tissue Bleeding During Open Abdominal, Retroperitoneal, Pelvic, Thoracic (Non-cardiac) and Extremity SurgeryBenjamin SamsteinPIInterventionDevice: ETHIZIA · Device: SURGICEL OriginalDatesApr 2025 – Sep 2026SponsorEthicon INCHemostasisHemostatic Techniques
CompletedInterventional · Not applicableNCT06676072 ↗Safety and Effectiveness of the TactiFlex SE Catheter and Volt Pulsed Field Ablation (PFA) Generator in Subjects With Paroxysmal Atrial FibrillationSteven M MarkowitzPIInterventionDevice: PFA Ablation catheterDatesNov 2024 – Apr 2026SponsorAbbott Cardiovascular Systems, Inc.Atrial Fibrillation (AF)Atrial ArrhythmiaParoxysmal AF+1 more
CompletedInterventional · Phase 3NCT06868264 ↗Phase 3, Randomized, Controlled, Open-label Study to Compare the Efficacy and Safety of Bemnifosbuvir-Ruzasvir Fixed-dose Combination (BEM/RZR FDC) Versus Sofosbuvir-Velpatasvir Fixed-dose Combination (SOF/VEL FDC) in Subjects With Chronic Hepatitis C Virus (HCV) InfectionIlan Seth WeisbergPIInterventionDrug: Bemnifosbuvir-Ruzasvir (BEM/RZR) · Drug: Sofosbuvir-Velpatasvir (SOF/VEL)DatesApr 2025 – Jun 2026SponsorAtea Pharmaceuticals, Inc.HEPATITIS C VIRUS CHRONIC INFECTION
TerminatedInterventional · Phase 1/2NCT06983158 ↗A Phase 1/2a, Open-Label, Multi-Center, Dose-Escalation Trial to Assess Safety, Tolerability, and Efficacy of a Single Dose of CAP-002 Gene Therapy Administered to Pediatric Patients With Syntaxin-Binding Protein 1 (STXBP1) EncephalopathyZachary GrinspanPIInterventionDrug: gene therapyDatesJul 2025 – Mar 2026SponsorCapsida Biotherapeutics, Inc.Developmental and Epileptic Encephalopathy
CompletedInterventional · Not applicableNCT06994325 ↗A Pilot Hybrid Effectiveness-Implementation Trial for the Conversations Helpful for Awareness of Illness Trajectory (CHAT) InterventionParag GoyalPIInterventionBehavioral: Conversations Helpful for Awareness of Illness Trajectory (CHAT) Intervention · Behavioral: Standard of Care (SOC)DatesJul 2025 – Aug 2026SponsorWeill Medical College of Cornell UniversityHFpEF - Heart Failure With Preserved Ejection Fraction
CompletedInterventional · Phase 2NCT07144293 ↗Improving Physical Ability and Cellular Senescence Elimination in HIVCarrie JohnstonPIInterventionDrug: Dasatinib · Drug: Quercetin · Other: Placebo - Dasatinib · Other: Placebo - QuercetinDatesDec 2025 – Aug 2026SponsorNational Institute of Allergy & Infectious DiseasesHIVFrailtyPrefrail+1 more