CompletedInterventional · Phase 2NCT01622868 ↗Phase II Randomized Study of Whole Brain Radiotherapy/Stereotactic Radiosurgery in Combination With Concurrent Lapatinib in Patients With Brain Metastasis From HER2-Positive Breast Cancer - A Collaborative Study of NRG Oncology and KROG
CompletedInterventional · Phase 2/3NCT02635009 ↗Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung CancerHani Lamie AshamallaPIInterventionRadiation: Three-Dimensional Conformal Radiation Therapy · Radiation: Intensity-Modulated Radiation TherapyDatesDec 2015 – May 2023· Results postedSponsorNRG OncologyExtensive Stage Small Cell Lung CarcinomaLimited Stage Small Cell Lung Carcinoma
CompletedInterventional · Phase 3NCT03776071 ↗A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Enzastaurin Added to Temozolomide During and Following Radiation Therapy in Newly Diagnosed Glioblastoma Patients Who Possess the Novel Genomic Biomarker DGM1Howard Alan FinePIInterventionDrug: Enzastaurin Hydrochloride · Other: Placebo · Drug: Temozolomide · Radiation: RadiotherapyDatesDec 2020 – Feb 2024SponsorDenovo BiopharmaGlioblastoma
CompletedInterventional · Phase 1/2NCT04037254 ↗Randomized Phase II Trial of Niraparib With Standard Combination Radiotherapy and Androgen Deprivation Therapy (ADT) in High Risk Prostate Cancer (With Initial Phase I) (NADIR*) *Randomized Phase II Trial of Niraparib With Standard Combination Androgen DeprIvation Therapy (ADT) and Radiotherapy in High Risk Prostate Cancer (With Initial Phase I)David A. GreenPIInterventionBiological: Gonadotrophin Releasing Hormone · Radiation: Intensity-Modulated Radiation Therapy · Drug: NiraparibDatesOct 2019 – Jul 2024· Results postedSponsorNRG OncologyProstate AdenocarcinomaStage IIC Prostate Cancer AJCC v8Stage III Prostate Cancer AJCC v8+4 more
CompletedInterventional · Phase 3NCT04210115 ↗A Randomized, Double-blind, Placebo-controlled Phase 3 Trial of Pembrolizumab (MK-3475) Versus Placebo in Participants With Esophageal Carcinoma Receiving Concurrent Definitive Chemoradiotherapy (KEYNOTE 975)Manish A ShahPIInterventionBiological: pembrolizumab · Drug: placebo · Drug: cisplatin · Drug: 5-FU · Radiation: radiotherapy · Drug: leucovorin · Drug: levoleucovorin · Drug: oxaliplatinDatesFeb 2020 – Jan 2026SponsorMerck Sharp & Dohme CorpEsophageal Squamous Cell Carcinoma (ESCC)Gastroesophageal Junction Carcinoma (GEJC)Esophageal Adenocarcinoma (EAC)
CompletedInterventional · Not applicableNCT04220983 ↗PRAGMA (Prostate Radio Ablation Guided by Magnetic Resonance Imaging Acquisition) in Metastatic Prostate CancerSilvia Chiara FormentiPIInterventionRadiation: MR-Guided Prostate SBRTDatesJan 2020 – Feb 2023· Results postedSponsorWeill Medical College of Cornell UniversityMetastatic Prostate Cancer
CompletedInterventional · Phase 2/3NCT04396860 ↗A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab Versus Temozolomide in Patients With Newly Diagnosed MGMT (Tumor O-6-Methylguanine DNA Methyltransferase) Unmethylated GlioblastomaRajiv S. MaggePIInterventionProcedure: Contrast-enhanced Magnetic Resonance Imaging · Biological: Ipilimumab · Biological: Nivolumab · Device: NovoTTF-100A Device · Other: Quality-of-Life Assessment · Other: Questionnaire Administration · Radiation: Radiation Therapy · Drug: TemozolomideDatesSep 2020 – Jan 2023· Results postedSponsorNRG OncologyGliosarcomaMGMT-Unmethylated Glioblastoma