Active, not recruitingInterventional · Phase 2/3NCT03604991 ↗A Phase II/III Study of Peri-Operative Nivolumab and Ipilimumab in Patients With Locoregional Esophageal and Gastroesophageal Junction Adenocarcinoma
Active, not recruitingInterventional · Phase 2/3NCT05610163 ↗The Janus Rectal Cancer Trial: A Randomized Phase II/III Trial Testing the Efficacy of Triplet Versus Doublet Chemotherapy Regarding Clinical Complete Response and Disease-free Survival in Patients With Locally Advanced Rectal CancerUqba KhanPIInterventionDrug: Capecitabine · Drug: 5-fluorouracil · Drug: Leucovorin calcium · Drug: Irinotecan · Drug: Oxaliplatin · Radiation: Long Course Chemoradiotherapy · Procedure: Computed Tomography · Procedure: Magnetic Resonance Imaging · Procedure: Sigmoidoscopy · Procedure: biopsyDatesDec 2022 – Jul 2030 (est.)SponsorAlliance for Clinical Trials in OncologyStage II Rectal Cancer AJCC v8Stage III Rectal Cancer AJCC v8Locally Advanced Rectal Adenocarcinoma
CompletedInterventional · Phase 2/3NCT02635009 ↗Randomized Phase II/III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small Cell Lung CancerHani Lamie AshamallaPIInterventionRadiation: Three-Dimensional Conformal Radiation Therapy · Radiation: Intensity-Modulated Radiation TherapyDatesDec 2015 – May 2023· Results postedSponsorNRG OncologyExtensive Stage Small Cell Lung CarcinomaLimited Stage Small Cell Lung Carcinoma
CompletedInterventional · Phase 2/3NCT04396860 ↗A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab Versus Temozolomide in Patients With Newly Diagnosed MGMT (Tumor O-6-Methylguanine DNA Methyltransferase) Unmethylated GlioblastomaRajiv S. MaggePIInterventionProcedure: Contrast-enhanced Magnetic Resonance Imaging · Biological: Ipilimumab · Biological: Nivolumab · Device: NovoTTF-100A Device · Other: Quality-of-Life Assessment · Other: Questionnaire Administration · Radiation: Radiation Therapy · Drug: TemozolomideDatesSep 2020 – Jan 2023· Results postedSponsorNRG OncologyGliosarcomaMGMT-Unmethylated Glioblastoma