RecruitingInterventional · Phase 2NCT05507138 ↗Efficacy and Target Engagement of a Digital Intervention to Improve Depression and Executive Dysfunction After StrokeAbhishek Jaywant
RecruitingInterventional · Phase 2NCT05816603 ↗Home-based Post-stroke Fatigue Treatment Using Transcranial Direct Current Stimulation (tDCS)Joan StillingPIInterventionDevice: Real Soterix Mini-CT tDCS stimulator · Device: Sham Soterix Mini-CT tDCS stimulatorDatesMay 2023 – Dec 2027 (est.)SponsorWeill Medical College of Cornell UniversityFatigueStroke Rehabilitaion
RecruitingInterventional · Phase 2NCT06502964 ↗Double-Blind, Placebo-Controlled Study of ALTO-101 in Patients With Schizophrenia and Cognitive ImpairmentAnthony O. AhmedPIInterventionDrug: ALTO-101 · Device: ALTO-101 Transdermal Delivery System · Drug: Placebo · Device: Placebo Transdermal Delivery SystemDatesJun 2024 – Feb 2026 (est.)SponsorAlto NeuroscienceSchizophreniaCognitive Impairment
CompletedInterventional · Phase 2NCT03603808 ↗A Phase 2 Evaluation of VGX-3100, a Synthetic DNA Immunotherapy Targeting Human Papillomavirus 16 and 18 E6 and E7 Proteins, for Anal High-Grade Squamous Intraepithelial Lesions (HSIL) in HIV-Positive IndividualsGrant EllsworthPIInterventionDevice: Electroporation · Biological: HPV DNA Plasmids Therapeutic Vaccine VGX-3100 · Other: Laboratory Biomarker AnalysisDatesSep 2018 – Dec 2024· Results postedSponsorAIDS Malignancy ConsortiumAnal Intraepithelial NeoplasiaHigh Grade Squamous Intraepithelial NeoplasiaHIV Positivity+2 more
CompletedInterventional · Phase 2NCT04456998 ↗A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Clinical Study to Evaluate the Efficacy and Safety of Oral Inhalation of GB002 for the Treatment of WHO Group 1 Pulmonary Arterial Hypertension (PAH)Irina SobolPIInterventionDrug: GB002 (seralutinib) · Drug: Placebo · Device: Generic Dry Powder InhalerDatesNov 2020 – Oct 2022· Results postedSponsorGossamer BioPulmonary Artery Hypertension
TerminatedInterventional · Phase 2NCT04816604 ↗An Open-label Extension Study Evaluating the Long-term Safety and Efficacy of Oral Inhalation of GB002 for the Treatment of WHO Group 1 Pulmonary Arterial Hypertension (PAH)Irina SobolPIInterventionDrug: GB002 (seralutinib) · Device: Generic Dry Powder InhalerDatesApr 2021 – Sep 2026SponsorGossamer BioPulmonary Arterial Hypertension
CompletedInterventional · Phase 2NCT04843930 ↗Improving Cognitive Health in COVID-19 Survivors Through Digital TherapeuticsFaith GunningPIInterventionDevice: AKL-T01DatesJul 2021 – Feb 2023· Results postedSponsorWeill Medical College of Cornell UniversityCognitive DysfunctionCovid19
CompletedInterventional · Phase 2NCT04996797 ↗A Phase 2, Multi-Center, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Induction Therapy With PRA023 in Subjects With Moderately to Severely Active Ulcerative ColitisRandy LongmanPIInterventionDrug: Tulisokibart · Device: Companion Diagnostic (CDx) Testing · Other: PlaceboDatesJul 2021 – Jun 2023· Results postedSponsorPrometheus Biosciences, IncUlcerative Colitis