RecruitingInterventional · Not applicableNCT05064709 ↗Assessment of Implantable CCM in the Heart Failure Group With Higher Ejection Fraction
Active, not recruitingInterventional · Not applicableNCT05855135 ↗Assessment of the Safety and Efficacy of a Combined Cardiac Contractility Modulation and Implantable Cardioverter Defibrillator Device for Subjects With Heart Failure and Reduced Ejection FractionJames E. IpPIInterventionDevice: OPTIMIZER® Integra CCM-D System (Treatment Arm)DatesMay 2023 – Dec 2025SponsorImpulse Dynamics USA, Inc.Heart FailureHeart Failure With Reduced Ejection FractionImplantable Defibrillator User+7 more
RecruitingObservationalNCT07098858 ↗The WiSE®-UP Study (The WiSE System Utilization & Performance Study)James E. IpPIInterventionDevice: The Wise SystemDatesNov 2025 – Sep 2032 (est.)SponsorEBR Systems, IncHeart Failure
RecruitingInterventional · Not applicableNCT07118358 ↗BIOTRONIK Investigation of the LivIQ Leadless Pacemaker SystemJames E. IpPIInterventionDevice: LivIQ Leadless Pacemaker SystemDatesMar 2026 – Mar 2027 (est.)SponsorBIOTRONIK, Inc.Leadless PacemakerBradycardiaAV Block+1 more
CompletedInterventional · Not applicableNCT01816776 ↗A Randomized Trial Evaluating the Safety and Effectiveness of the remedē® System in Patients With Central Sleep ApneaJames E. IpPIInterventionDevice: Treatment Group (transvenous stimulation of the phrenic nerve) · Device: Control Group (Optimal Medical Therapy)DatesMar 2013 – Sep 2016· Results postedSponsorRespicardia, IncSleep Apnea, CentralSleep Disordered BreathingHeart Failure
CompletedInterventional · Not applicableNCT02030418 ↗The LEADLESS II IDE Study (Phase I): Safety and Effectiveness Trial for the Nanostim Leadless PacemakerJames E. IpPIInterventionDevice: Leadless PacemakerDatesFeb 2014 – Jun 2015· Results postedSponsorSt. Jude Medical FoundationBradycardia
CompletedInterventional · Not applicableNCT04559945 ↗The LEADLESS II IDE Study (Phase II): A Safety and Effectiveness Trial for a Leadless Pacemaker SystemJames E. IpPIInterventionDevice: Aveir VR Leadless Pacemaker SystemDatesNov 2020 – Jul 2022· Results postedSponsorAbbott Cardiovascular Systems, Inc.Cardiac Rhythm DisorderBradycardia
CompletedInterventional · Phase 3NCT04952610 ↗An Open Label Extension Study of Etripamil Nasal Spray in Patients With Paroxysmal Supraventricular TachycardiaJames E. IpPIInterventionDrug: Etripamil NS 70 mg · Device: Aptar Pharma Nasal Spray Bidose SystemDatesDec 2021 – Apr 2026SponsorMilestone PharmaceuticalsParoxysmal Supraventricular Tachycardia