Active, not recruitingInterventional · Not applicableNCT04226547 ↗Clinical Trial of Atrial Fibrillation Patients Comparing Left Atrial Appendage Occlusion Therapy to Non-vitamin K Antagonist Oral Anticoagulants
RecruitingInterventional · Not applicableNCT04339699 ↗STITCH - Prospective Multi Center Comparative Parallel Concurrent Study of the NobleStitch EL Compared to FDA Approved Amplatzer Occluder Device for Closure of Patent Foramen Ovale to Prevent Recurrent Ischemic StrokeHarsimran SinghPIInterventionDevice: NobleStitch™EL Suture Mediated Closure System · Device: Amplatzer PFO OccluderDatesJan 2021 – Dec 2026 (est.)SponsorNobles Medical Technologies II, Inc.Foramen Ovale, PatentStroke, Ischemic
Active, not recruitingInterventional · Not applicableNCT04818645 ↗Insertable Cardiac Monitor for Primary Atrial Fibrillation Detection in High-Risk Heart Failure Patients (ASSERT-AF)Gioia TurittoPIInterventionDevice: ASSERT Insertable Cardiac Monitor · Other: Conventional Management and monitoringDatesJan 2023 – Jul 2028 (est.)SponsorUniversity of RochesterAtrial FibrillationHeart Failure
Active, not recruitingInterventional · Phase 4NCT05284747 ↗EVOLVE-MI: A Pragmatic Randomized Multicenter Trial of EVOLocumab Administered Very Early to Reduce the Risk of Cardiovascular Events in Patients Hospitalized With Acute Myocardial InfarctionSamuel KimPIInterventionDrug: Evolocumab · Drug: Routine Lipid ManagementDatesOct 2022 – May 2027 (est.)SponsorAmgen, Inc.Cardiovascular DiseaseMyocardial InfarctionStroke+1 more
RecruitingInterventional · Phase 2NCT05507138 ↗Efficacy and Target Engagement of a Digital Intervention to Improve Depression and Executive Dysfunction After StrokeAbhishek JaywantPIInterventionDevice: AKL-T01 · Behavioral: Metacognitive Strategy TrainingDatesMar 2023 – Jun 2027 (est.)SponsorWeill Medical College of Cornell UniversityExecutive DysfunctionDepressionStroke
RecruitingInterventional · Not applicableNCT05723926 ↗Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral AnticoagulationHooman KamelPIInterventionDevice: Vine FilterDatesJan 2026 – Dec 2028 (est.)SponsorJavelin Medical Ltd.Atrial FibrillationOral AnticoagulationStroke+1 more
RecruitingInterventional · Not applicableNCT06689878 ↗Mobile Cognitive Behavioral Therapy for StrokeAbhishek JaywantPIInterventionDevice: Mobile CBT for StrokeDatesFeb 2025 – Mar 2028 (est.)SponsorWeill Medical College of Cornell UniversityAnxietyStrokeDepression
Not yet recruitingInterventional · Phase 3NCT07174414 ↗Cilostazol for Prevention of Recurrent Stroke TrialAva L LibermanPIInterventionDrug: Cilostazol 100 mg Tablets · Drug: PlaceboDatesOct 2026 – Jul 2031 (est.)SponsorStanford UniversityStroke RecurrenceMyocardial InfarctionVascular Death+4 more
RecruitingInterventional · Not applicableNCT07447934 ↗Vibrotactile Stimulation for Lower Limb SpasticityJoan StillingPIInterventionDevice: Vibrotactile Stimulation (Static Use) · Device: Vibrotactile Stimulation (Dynamic Use) · Device: Vibrotactile Stimulation (Neurophysiological Mechanism)DatesApr 2026 – Jun 2027 (est.)SponsorWeill Medical College of Cornell UniversityLower Limb Spasticity
RecruitingInterventional · Not applicableNCT07639606 ↗Mobile Cognitive Behavioral Therapy in Early Stroke RecoveryAbhishek JaywantPIInterventionDevice: Mobile Cognitive Behavioral Therapy AppDatesNov 2026 – Mar 2029 (est.)SponsorWeill Medical College of Cornell UniversityAnxietyStrokeDepression - Major Depressive Disorder
CompletedInterventional · Phase 3NCT04023552 ↗A Randomized Double-blind, Placebo-controlled, Multicenter Trial Assessing the Impact of Lipoprotein (a) Lowering With Pelacarsen (TQJ230) on Major Cardiovascular Events in Patients With Established Cardiovascular DiseaseSamuel KimPIInterventionDrug: TQJ230 · Drug: PlaceboDatesDec 2019 – Jul 2026SponsorNovartis Pharmaceuticals CorporationCardiovascular Disease and Lipoprotein(a)
TerminatedInterventional · Not applicableNCT04098835 ↗A Pilot Study of a Strategy and Computer-based Intervention to Enhance Daily Cognitive Functioning After StrokeAbhishek JaywantPIInterventionBehavioral: ASCENDDatesDec 2019 – Feb 2020SponsorWeill Medical College of Cornell UniversityStroke