RecruitingInterventional · Phase 4NCT04262206 ↗PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)Parag GoyalPIInterventionDrug: Atorvastatin 40 Mg Oral Tablet · Drug: Placebo oral tabletDatesSep 2020 – Dec 2026 (est.)
RecruitingInterventional · Not applicableNCT05081596 ↗PATH-Pain: A Primary Care-Based Psychosocial Intervention To Improve Cognitive and Depression Outcomes in Older Adults With MCI and Early Stage ADDimitris N KiossesPIInterventionBehavioral: PATH-PainDatesJun 2022 – Jul 2027 (est.)SponsorWeill Medical College of Cornell UniversityDepressionPainCognitive Impairment
Active, not recruitingObservationalNCT05611918 ↗The Repeated Assessment of Survivors in ICH (REASSESS ICH)Santosh Bhaskar MurthyPIDatesMay 2023 – Dec 2026 (est.)SponsorThe Johns Hopkins UniversityIntra Cerebral HemorrhageICH - Intracerebral HemorrhageICH+10 more
Not yet recruitingInterventional · Not applicableNCT05811338 ↗Center for Research and Education on Aging and Technology Enhancement - CREATE VSara CzajaPIInterventionBehavioral: Project 1 - Phase 2: VR Program for Social, Activity, and Cognitive Engagement · Behavioral: Project 1 - Phase 2: Tablet for Social, Activity, and Cognitive EngagementDatesOct 2026 – May 2027 (est.)SponsorWeill Medical College of Cornell UniversityMild Cognitive Impairment
RecruitingInterventional · Not applicableNCT06168604 ↗The Pain Identification and Communication Toolkit: A Training Program to Support Family Caregivers of Persons With ADRDCatherine RiffinPIInterventionBehavioral: Pain Identification and Communication Toolkit · Behavioral: Health Promotion ProgramDatesDec 2023 – Oct 2027 (est.)SponsorWeill Medical College of Cornell UniversityCaregiver BurdenCognitive ImpairmentDementia+2 more
RecruitingObservationalNCT06170268 ↗Alzheimer's National Registry for Treatment and DiagnosticsMiran W SalgadoPISonja BlumPIInterventionOther: Routine Care DocumentationDatesOct 2022 – Dec 2032 (est.)SponsorAlzheimer's Association National OfficeAlzheimer Disease
Active, not recruitingInterventional · Phase 2NCT06223360 ↗A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo- Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)Anna Starikovsky NordvigPIInterventionDrug: Low Dose Benfotiamine · Drug: High Dose Benfotiamine · Drug: PlaceboDatesMar 2024 – Dec 2027 (est.)SponsorWinifred Masterson Burke Medical ResearchAlzheimer Disease
RecruitingInterventional · Phase 2NCT06502964 ↗Double-Blind, Placebo-Controlled Study of ALTO-101 in Patients With Schizophrenia and Cognitive ImpairmentAnthony O. AhmedPIInterventionDrug: ALTO-101 · Device: ALTO-101 Transdermal Delivery System · Drug: Placebo · Device: Placebo Transdermal Delivery SystemDatesJun 2024 – Feb 2026 (est.)SponsorAlto NeuroscienceSchizophreniaCognitive Impairment
Active, not recruitingInterventional · Phase 3NCT07169578 ↗A Phase III, Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Efficacy and Safety Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease (MCI to Mild Dementia Due to AD)Sonja BlumPIInterventionDrug: Trontinemab · Other: PlaceboDatesSep 2025 – Feb 2028 (est.)SponsorF. Hoffman La-Roche LtdAlzheimers Disease
RecruitingInterventional · Phase 2NCT07553338 ↗Safety Assessment of Leronlimab and Its Effect on Neuroinflammation Targets in Alzheimer's DiseaseTracy A. ButlerPIInterventionDrug: Leronlimab (700mg)DatesApr 2026 – Nov 2027 (est.)SponsorWeill Medical College of Cornell UniversityMild Cognitive Impairment (MCI) Due to Alzheimer's DiseaseAlzheimer's Disease
CompletedInterventional · Phase 2NCT03649724 ↗The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer'sTracy A. ButlerPIInterventionDrug: Placebo · Drug: Eligard 22.5Mg Suspension for InjectionDatesNov 2020 – Jul 2026SponsorWeill Medical College of Cornell UniversityAlzheimer DiseaseMild Cognitive Impairment
CompletedObservationalNCT04426539 ↗New IDEAS: Imaging Dementia-Evidence for Amyloid Scanning Study - A Study to Improve Precision in Amyloid PET Coverage and Patient CareTracy A. ButlerPIDatesDec 2020 – Dec 2024SponsorAmerican College of RadiologyAlzheimer's DiseaseDementiaMild Cognitive Impairment
TerminatedInterventional · Not applicableNCT04472351 ↗Strategy Training for Cognitive Dysfunction in Inpatient Stroke RehabilitationAbhishek JaywantPIInterventionBehavioral: ASCEND-IDatesJan 2021 – Sep 2022SponsorWeill Medical College of Cornell UniversityExecutive DysfunctionCognitive Impairment
CompletedInterventional · Phase 2NCT04843930 ↗Improving Cognitive Health in COVID-19 Survivors Through Digital TherapeuticsFaith GunningPIInterventionDevice: AKL-T01DatesJul 2021 – Feb 2023· Results postedSponsorWeill Medical College of Cornell UniversityCognitive DysfunctionCovid19