Active, not recruitingInterventional · Phase 2NCT06223360 ↗A Seamless Phase 2A-Phase 2B Randomized Double-Blind Placebo- Controlled Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)
RecruitingInterventional · Phase 2NCT06502964 ↗Double-Blind, Placebo-Controlled Study of ALTO-101 in Patients With Schizophrenia and Cognitive ImpairmentAnthony O. AhmedPIInterventionDrug: ALTO-101 · Device: ALTO-101 Transdermal Delivery System · Drug: Placebo · Device: Placebo Transdermal Delivery SystemDatesJun 2024 – Feb 2026 (est.)SponsorAlto NeuroscienceSchizophreniaCognitive Impairment
RecruitingInterventional · Phase 2NCT07553338 ↗Safety Assessment of Leronlimab and Its Effect on Neuroinflammation Targets in Alzheimer's DiseaseTracy A. ButlerPIInterventionDrug: Leronlimab (700mg)DatesApr 2026 – Nov 2027 (est.)SponsorWeill Medical College of Cornell UniversityMild Cognitive Impairment (MCI) Due to Alzheimer's DiseaseAlzheimer's Disease
CompletedInterventional · Phase 2NCT03649724 ↗The LUCINDA Trial: LeUprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer'sTracy A. ButlerPIInterventionDrug: Placebo · Drug: Eligard 22.5Mg Suspension for InjectionDatesNov 2020 – Jul 2026SponsorWeill Medical College of Cornell UniversityAlzheimer DiseaseMild Cognitive Impairment
CompletedInterventional · Phase 2NCT04843930 ↗Improving Cognitive Health in COVID-19 Survivors Through Digital TherapeuticsFaith GunningPIInterventionDevice: AKL-T01DatesJul 2021 – Feb 2023· Results postedSponsorWeill Medical College of Cornell UniversityCognitive DysfunctionCovid19