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Frederick R. Maxfield, PhD
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Co-authored with Abigail Haka
Co-authored publications
Frederick R. Maxfield, PhD and Abigail Haka · 16 publications
CSV
Word
High-density lipoprotein or cyclodextrin extraction of cholesterol from aggregated LDL reduces foam cell formation.
Journal of cell science
· 2019
FR
Frederick R. Maxfield
AS
Abigail S Haka
PMID:
31719160
·
PMCID:
PMC6918773
·
DOI
·
17 citations
·
Abstract
TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates.
Arteriosclerosis, thrombosis, and vascular biology
· 2019
FR
Frederick R. Maxfield
AS
Abigail S Haka
VC
Valéria C Barbosa-Lorenzi
TH
Timothy Hla
PMID:
31597445
·
PMCID:
PMC6928397
·
DOI
·
67 citations
·
Abstract
Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL (Low-Density Lipoprotein) Uptake and Catabolism.
Arteriosclerosis, thrombosis, and vascular biology
· 2019
FR
Frederick R. Maxfield
AS
Abigail S Haka
PB
Priya Bhardwaj
PMID:
30580573
·
PMCID:
PMC6344252
·
DOI
·
31 citations
·
Abstract
Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity.
Cell reports
· 2017
FR
Frederick R. Maxfield
AS
Abigail S Haka
VC
Valéria C Barbosa-Lorenzi
PMID:
28954231
·
PMCID:
PMC5646237
·
DOI
·
255 citations
·
Abstract
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux.
ACS nano
· 2017
FR
Frederick R. Maxfield
AS
Abigail S Haka
TV
Thomas V Galassi
CP
Christopher P Horoszko
+3 more →
DA
Daniel A Heller
PMID:
28898055
·
PMCID:
PMC5707631
·
DOI
·
115 citations
·
Abstract
Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism.
Journal of lipid research
· 2017
FR
Frederick R. Maxfield
AS
Abigail S Haka
AB
Alexandria Brumfield
PB
Priya Bhardwaj
TH
Timothy Hla
PMID:
28814641
·
PMCID:
PMC5625121
·
DOI
·
24 citations
·
Abstract
Sphingosine kinases are not required for inflammatory responses in macrophages.
The Journal of biological chemistry
· 2016
FR
Frederick R. Maxfield
AS
Abigail S Haka
AJ
Andrew J Dannenberg
PMID:
27226645
·
PMCID:
PMC4900292
·
DOI
·
3 citations
Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation.
Journal of lipid research
· 2016
FR
Frederick R. Maxfield
AS
Abigail S Haka
VC
Valéria C Barbosa-Lorenzi
DJ
Domenick J. Falcone
CA
Clifford A Hudis
+1 more →
PMID:
27044658
·
PMCID:
PMC4878183
·
DOI
·
109 citations
·
Abstract
Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse.
Journal of cell science
· 2016
FR
Frederick R. Maxfield
AS
Abigail S Haka
VC
Valéria C Barbosa-Lorenzi
PMID:
26801085
·
PMCID:
PMC4813320
·
DOI
·
35 citations
·
Abstract
Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation.
Arteriosclerosis, thrombosis, and vascular biology
· 2015
FR
Frederick R. Maxfield
AS
Abigail S Haka
EC
Estibaliz Capetillo-Zarate
NA
Niroshana Anandasabapathy
PMID:
26293468
·
PMCID:
PMC4583358
·
DOI
·
35 citations
·
Abstract
Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.
ChemMedChem
· 2014
FR
Frederick R. Maxfield
AS
Abigail S Haka
RS
Robert S Runyon
PMID:
25504894
·
PMCID:
PMC4471478
·
DOI
·
32 citations
·
Abstract
Sphingosine kinases are not required for inflammatory responses in macrophages.
The Journal of biological chemistry
· 2013
FR
Frederick R. Maxfield
AS
Abigail S Haka
AJ
Andrew J Dannenberg
TH
Timothy Hla
PMID:
24081141
·
PMCID:
PMC3820889
·
DOI
·
64 citations
·
Abstract
Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.
Arteriosclerosis, thrombosis, and vascular biology
· 2013
FR
Frederick R. Maxfield
AS
Abigail S Haka
PMID:
23702659
·
PMCID:
PMC3716867
·
DOI
·
19 citations
·
Abstract
Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy.
PloS one
· 2012
FR
Frederick R. Maxfield
AS
Abigail S Haka
PMID:
23024767
·
PMCID:
PMC3443108
·
DOI
·
21 citations
·
Abstract
Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins.
Molecular biology of the cell
· 2009
FR
Frederick R. Maxfield
AS
Abigail S Haka
PMID:
19812252
·
PMCID:
PMC2785736
·
DOI
·
112 citations
·
Abstract
Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization.
Arteriosclerosis, thrombosis, and vascular biology
· 2009
FR
Frederick R. Maxfield
AS
Abigail S Haka
PMID:
19556523
·
PMCID:
PMC2755184
·
DOI
·
44 citations
·
Abstract