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David C Lyden, PhD, MD
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Co-authored with Lee Shaashua Berger
Co-authored publications
David C Lyden, PhD, MD and Lee Shaashua Berger · 7 publications
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Tumoral extracellular vesicles and particles reprogram interstitial macrophages in the lung to promote vascular permeability and metastasis.
Nature cancer
· 2026
PMID:
42557402
·
PMCID:
PMC13498464
·
DOI
·
1 citations
·
Abstract
Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2.
Cell
· 2025
PMID:
39938515
·
PMCID:
PMC12452024
·
DOI
·
66 citations
·
Abstract
Unique structural configuration of EV-DNA primes Kupffer cell-mediated antitumor immunity to prevent metastatic progression.
Nature cancer
· 2024
PMID:
39627554
·
PMCID:
PMC12185067
·
DOI
·
44 citations
·
Abstract
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer.
Nature medicine
· 2024
PMID:
38942992
·
PMCID:
PMC11416063
·
DOI
·
71 citations
·
Abstract
Tumour-derived Extracellular Vesicle and Particle Reprogramming of Interstitial Macrophages in the Lung Pre-Metastatic Niche Enhances Vascular Permeability and Metastatic Potential.
Research square
· 2024
PMID:
38853850
·
PMCID:
PMC11160910
·
DOI
·
Abstract
Immune determinants of the pre-metastatic niche.
Cancer cell
· 2023
PMID:
36917952
·
PMCID:
PMC10170403
·
DOI
·
223 citations
·
Abstract
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.
Nature communications
· 2022
PMID:
36316305
·
PMCID:
PMC9622893
·
DOI
·
67 citations
·
Abstract