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Chun-Jun Guo, PhD
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Co-authored with Wenbing Jin
Co-authored publications
Chun-Jun Guo, PhD and Wenbing Jin · 18 publications
CSV
Word
Transferable genetic toolsets for nonmodel gut Clostridia enable in vivo reversible control of metabolite production.
Nature biotechnology
· 2026
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
TL
Ting-Ting Li
FW
Fangzhao Wang
LX
Leyi Xiao
+1 more →
PMID:
42642483
·
DOI
·
Abstract
Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism.
Nature metabolism
· 2026
CG
Chun-Jun Guo
WJ
Wenbing Jin
ZL
Zhongchi Li
LX
Leyi Xiao
+12 more →
JB
John Blenis
PMID:
42625032
·
PMCID:
PMC13493318
·
DOI
·
Abstract
Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity.
Cell host & microbe
· 2026
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
SQ
Shanshan Qiao
TL
Ting-Ting Li
MJ
Mingeum Jeong
+13 more →
PMID:
41483801
·
PMCID:
PMC13130079
·
DOI
·
11 citations
·
Abstract
Microbiota-derived bile acids antagonize the host androgen receptor and drive anti-tumor immunity.
Cell
· 2025
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
LX
Leyi Xiao
MJ
Mingeum Jeong
WZ
Wen Zhang
+9 more →
PMID:
40239649
·
PMCID:
PMC12439225
·
DOI
·
67 citations
·
Abstract
Host metabolism balances microbial regulation of bile acid signalling.
Nature
· 2025
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
MA
Mohammad Arifuzzaman
CP
Christopher Parkhurst
SK
Sangeeta Kashyap
+1 more →
PMID:
39779854
·
PMCID:
PMC11886927
·
DOI
·
65 citations
·
Abstract
Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation.
Microbiome
· 2024
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
PMID:
38730492
·
PMCID:
PMC11084060
·
DOI
·
7 citations
·
Abstract
Microbiota metabolism of intestinal amino acids impacts host nutrient homeostasis and physiology.
Cell host & microbe
· 2024
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
TL
Ting-Ting Li
XC
Xi Chen
MA
Mohammad Arifuzzaman
+3 more →
PMID:
38657606
·
PMCID:
PMC11636940
·
DOI
·
213 citations
·
Abstract
Dietary fiber is a critical determinant of pathologic ILC2 responses and intestinal inflammation.
The Journal of experimental medicine
· 2024
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
MA
Mohammad Arifuzzaman
HY
Hiroshi Yano
+4 more →
DA
David Artis
PMID:
38506708
·
PMCID:
PMC10955042
·
DOI
·
48 citations
·
Abstract
The gut microbiome regulates the clinical efficacy of sulfasalazine therapy for IBD-associated spondyloarthritis.
Cell reports. Medicine
· 2024
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
SP
Silvia Pires
GA
Grace Anne Maldarelli
+6 more →
RL
Randy Longman
PMID:
38378002
·
PMCID:
PMC10982976
·
DOI
·
39 citations
·
Abstract
Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation.
bioRxiv : the preprint server for biology
· 2023
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
PMID:
37333296
·
PMCID:
PMC10274677
·
DOI
·
Abstract
Inulin fibre promotes microbiota-derived bile acids and type 2 inflammation.
Nature
· 2022
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
MA
Mohammad Arifuzzaman
TL
Ting-Ting Li
+7 more →
DA
David Artis
PMID:
36323778
·
PMCID:
PMC10576985
·
DOI
·
221 citations
·
Abstract
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression.
Nature communications
· 2022
CG
Chun-Jun Guo
WJ
Wenbing Jin
ZL
Zhongchi Li
VL
Vivien Low
+10 more →
JB
John Blenis
PMID:
36266345
·
PMCID:
PMC9584945
·
DOI
·
72 citations
·
Abstract
Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection.
Cell
· 2022
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
WZ
Wen Zhang
ML
Mengze Lyu
+5 more →
DA
David Artis
PMID:
36240781
·
PMCID:
PMC9617796
·
DOI
·
158 citations
·
Abstract
Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome.
Cell
· 2022
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
TL
Ting-Ting Li
SQ
Sophia Qu
XV
Xin V Li
+4 more →
PMID:
35051369
·
PMCID:
PMC8919858
·
DOI
·
152 citations
·
Abstract
Transferable Immunoglobulin A-Coated Odoribacter splanchnicus in Responders to Fecal Microbiota Transplantation for Ulcerative Colitis Limits Colonic Inflammation.
Gastroenterology
· 2021
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
SF
Svetlana F Lima
LG
Lasha Gogokhia
+4 more →
RL
Randy Longman
PMID:
34606847
·
PMCID:
PMC8678328
·
DOI
·
159 citations
·
Abstract
Adherent-invasive E. coli metabolism of propanediol in Crohn's disease regulates phagocytes to drive intestinal inflammation.
Cell host & microbe
· 2021
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
MV
Monica Viladomiu
ML
Maeva L Metz
+3 more →
RL
Randy Longman
PMID:
33539767
·
PMCID:
PMC8049981
·
DOI
·
98 citations
·
Abstract
Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells.
Nature
· 2020
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
CM
Cheryl Mai
AR
Alexander Rudensky
PMID:
32461639
·
PMCID:
PMC7540721
·
DOI
·
822 citations
·
Abstract
Boosting polyketides production in cell factories: Shared target-pathway for pharmaceutical polyketides engineering.
Synthetic and systems biotechnology
· 2020
CG
Chun-Jun Guo
WJ
Wen-Bing Jin
PMID:
32161822
·
PMCID:
PMC7058523
·
DOI
·
1 citations