Co-authored publications with mentees

Charles L. Sawyers, MD · 13 publications across 2 mentees

CSV Word

MD-PhD mentee

Targeting Tumor Microenvironment-Derived NRG1-HER2/3 Signaling with Zenocutuzumab Restores Sensitivity to AR Inhibition in PTEN Wild-type Prostate Cancer.
Molecular cancer therapeutics · 2026
CLCharles L. SawyersYSYoung Sun LeeNMNinghui MaoAGAnuradha GopalanBSBrett S. Carver
PMID: 41379983PMCID: PMC13022569DOI
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L.
Nature genetics · 2025
CLCharles L. SawyersYSYoung Sun LeeAGAnuradha GopalanBSBrett S. Carver
PMID: 40858905PMCID: PMC12425824DOI10 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers.
Science advances · 2025
CLCharles L. SawyersYSYoung Sun LeeNMNinghui MaoBSBrett S. Carver
PMID: 39919177PMCID: PMC11804928DOI20 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity.
bioRxiv : the preprint server for biology · 2024
CLCharles L. SawyersYSYoung Sun LeeCSChristina S Leslie
PMID: 38585869PMCID: PMC10996491DOI
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers.
Nature communications · 2021
CLCharles L. SawyersYSYoung Sun LeeNRNeal RosenACAndrew C HsiehYCYu Chen
PMID: 34417459PMCID: PMC8379232DOI35 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Rapid interrogation of cancer cell of origin through CRISPR editing.
Proceedings of the National Academy of Sciences of the United States of America · 2021
CLCharles L. SawyersYSYoung Sun LeeZCZhen CaoMJMaria Jasin
PMID: 34353917PMCID: PMC8364185DOI20 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer.
Cancer cell · 2020
CLCharles L. SawyersYSYoung Sun LeeVRVianne R GaoXJXuejun Jiang
PMID: 32679108PMCID: PMC7472556DOI233 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation.
Cancer cell · 2020
CLCharles L. SawyersYSYoung Sun LeeKNKristina NavrazhinaZCZhen CaoCHChun-Hao Huang+3 more →
PMID: 32220301PMCID: PMC7292228DOI146 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2.
Cancer research · 2020
CLCharles L. SawyersYSYoung Sun LeeSGSunyana GadalNRNeal Rosen YCYu Chen
PMID: 32015092PMCID: PMC7127960DOI15 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance.
eLife · 2019
CLCharles L. SawyersYSYoung Sun Lee
PMID: 30644358PMCID: PMC6336405DOI20 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)

PhD mentee

Rapid interrogation of cancer cell of origin through CRISPR editing.
Proceedings of the National Academy of Sciences of the United States of America · 2021
CLCharles L. SawyersZCZhen CaoYSYoung Sun LeeMJMaria Jasin
PMID: 34353917PMCID: PMC8364185DOI20 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023
Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.
Cancer discovery · 2020
CLCharles L. SawyersZCZhen CaoTHTeng HanLELukas Edward DowSWScott W Lowe
PMID: 32376773PMCID: PMC7334089DOI45 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation.
Cancer cell · 2020
CLCharles L. SawyersZCZhen CaoYSYoung Sun LeeKNKristina NavrazhinaCHChun-Hao Huang+3 more →
PMID: 32220301PMCID: PMC7292228DOI146 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.
Science (New York, N.Y.) · 2017
CLCharles L. SawyersZCZhen CaoPMPing MuCCChi-Chao ChenWAWassim Abida+5 more →
PMID: 28059768PMCID: PMC5247742DOI911 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023
Organoid cultures derived from patients with advanced prostate cancer.
Cell · 2014
CLCharles L. SawyersZCZhen CaoASAndrea SbonerVKVivek K Arora+14 more →YCYu Chen
PMID: 25201530PMCID: PMC4237931DOI1,383 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023

Co-authored publications with mentees

Charles L. Sawyers, MD · 13 publications across 2 mentees

CSV Word

MD-PhD mentee

Targeting Tumor Microenvironment-Derived NRG1-HER2/3 Signaling with Zenocutuzumab Restores Sensitivity to AR Inhibition in PTEN Wild-type Prostate Cancer.
Molecular cancer therapeutics · 2026
CLCharles L. SawyersYSYoung Sun LeeNMNinghui MaoAGAnuradha GopalanBSBrett S. Carver
PMID: 41379983PMCID: PMC13022569DOI
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
ERG-driven prostate cancer initiation is cell-context dependent and requires KMT2A and DOT1L.
Nature genetics · 2025
CLCharles L. SawyersYSYoung Sun LeeAGAnuradha GopalanBSBrett S. Carver
PMID: 40858905PMCID: PMC12425824DOI10 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Uncoupling of Akt and mTOR signaling drives resistance to Akt inhibition in PTEN loss prostate cancers.
Science advances · 2025
CLCharles L. SawyersYSYoung Sun LeeNMNinghui MaoBSBrett S. Carver
PMID: 39919177PMCID: PMC11804928DOI20 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
ERG activates a stem-like proliferation-differentiation program in prostate epithelial cells with mixed basal-luminal identity.
bioRxiv : the preprint server for biology · 2024
CLCharles L. SawyersYSYoung Sun LeeCSChristina S Leslie
PMID: 38585869PMCID: PMC10996491DOI
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers.
Nature communications · 2021
CLCharles L. SawyersYSYoung Sun LeeNRNeal RosenACAndrew C HsiehYCYu Chen
PMID: 34417459PMCID: PMC8379232DOI35 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Rapid interrogation of cancer cell of origin through CRISPR editing.
Proceedings of the National Academy of Sciences of the United States of America · 2021
CLCharles L. SawyersYSYoung Sun LeeZCZhen CaoMJMaria Jasin
PMID: 34353917PMCID: PMC8364185DOI20 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer.
Cancer cell · 2020
CLCharles L. SawyersYSYoung Sun LeeVRVianne R GaoXJXuejun Jiang
PMID: 32679108PMCID: PMC7472556DOI233 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation.
Cancer cell · 2020
CLCharles L. SawyersYSYoung Sun LeeKNKristina NavrazhinaZCZhen CaoCHChun-Hao Huang+3 more →
PMID: 32220301PMCID: PMC7292228DOI146 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2.
Cancer research · 2020
CLCharles L. SawyersYSYoung Sun LeeSGSunyana GadalNRNeal Rosen YCYu Chen
PMID: 32015092PMCID: PMC7127960DOI15 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)
GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance.
eLife · 2019
CLCharles L. SawyersYSYoung Sun Lee
PMID: 30644358PMCID: PMC6336405DOI20 citations
With Young Sun Lee · MD-PhD WGS Cell & Developmental Biology (MD-PhD)

PhD mentee

Rapid interrogation of cancer cell of origin through CRISPR editing.
Proceedings of the National Academy of Sciences of the United States of America · 2021
CLCharles L. SawyersZCZhen CaoYSYoung Sun LeeMJMaria Jasin
PMID: 34353917PMCID: PMC8364185DOI20 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023
Somatic Tissue Engineering in Mouse Models Reveals an Actionable Role for WNT Pathway Alterations in Prostate Cancer Metastasis.
Cancer discovery · 2020
CLCharles L. SawyersZCZhen CaoTHTeng HanLELukas Edward DowSWScott W Lowe
PMID: 32376773PMCID: PMC7334089DOI45 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023
Loss of CHD1 Promotes Heterogeneous Mechanisms of Resistance to AR-Targeted Therapy via Chromatin Dysregulation.
Cancer cell · 2020
CLCharles L. SawyersZCZhen CaoYSYoung Sun LeeKNKristina NavrazhinaCHChun-Hao Huang+3 more →
PMID: 32220301PMCID: PMC7292228DOI146 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023
SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer.
Science (New York, N.Y.) · 2017
CLCharles L. SawyersZCZhen CaoPMPing MuCCChi-Chao ChenWAWassim Abida+5 more →
PMID: 28059768PMCID: PMC5247742DOI911 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023
Organoid cultures derived from patients with advanced prostate cancer.
Cell · 2014
CLCharles L. SawyersZCZhen CaoASAndrea SbonerVKVivek K Arora+14 more →YCYu Chen
PMID: 25201530PMCID: PMC4237931DOI1,383 citations
With Zhen Cao · Cell & Developmental Biology (PhD) · Class of 2023