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Overview

Dr. Marco Seandel is an Associate Professor of Cell and Developmental Biology in Surgery at Weill Cornell Medical College.  Dr. Seandel received his MD/PhD from the State University of New York at Stony Brook, completed his internal medicine residency at New York-Presbyterian/Weill Cornell Medical Center and his medical oncology fellowship at Memorial Sloan Kettering Cancer Center. His lab is keenly interested in the mechanisms by which monogenic and complex disorders become increasingly prevalent in children as a function of the father’s age at the time of conception. Projects in the laboratory relate to cancer risk, autism, and skeletal disorders among others.  The lab uses adult spermatogonial stem cells in vitro, stem cell transplantation, human genomics, and mouse models to understand the origin and mechanisms of human disease.

Publications

36 publications

Active

1 grant
  • MPI
    Negative feedback regulation of growth factor signaling in adult spermatogonial stem cells
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2021–2026
    R01HD101452-03
Completed grants (7)
  • MPI
    Methods for detection of dynamic intracellular signals in single adult spermatogonial stem cells
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2023–2025
    R21HD107212-01A1
  • PI
    The Paternal Germline as a Source of De Novo Cancer Risk in Offspring
    Starr Cancer Consortium · 2016–2019
    I9-A9-085
  • PI
    Generation and Functional Characterization of Primordial Germ Cells Derived From hESCs
    Tri-Institutional Stem Cell Initiative (Weill Cornell) · 2016–2019
    2016-007
  • PI
    Spermatogonial Stem Cells as a Source of De Novo Cancer Susceptibility Mutations
    Tri-Institutional Stem Cell Initiative (Weill Cornell) · 2013–2019
    TRI-SCI WC 14030395-04
  • MPI
    Pathogenic disruption of small RNA function by de novo mutations
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2017–2019 · via Cornell University - Ithaca
    P50HD076210-05
  • PI
    Stem Cell Competition as the Driver for Sporadic Human Diseases
    Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2013–2018
    DP2HD080352-03
  • Co-I
    A Shared Facility for the Derivation, Validation, and Distribution of Stem Cells for Disease Modeling
    New York State Stem Cell Science (NYSTEM) · 2014–2018
    C029156