Overview
I am a computational biologist interested in human genetics. I seek to discover the mechanism whereby an individual’s genome and environment interact to produce disease, and to use this knowledge to develop a cure.
I began my career as a Biology undergraduate at MIT, where my first research project as an undergraduate was to invent a method for attaching DNA to glass as part of the then-unfinished Human Genome Project. My career has evolved in parallel with the Human Genome Project and the field of human genetics, from biology to bioinformatics then GWAS and now genomics.
After exploring career options in medical school, Silicon Valley, and the NIH I subsequently earned a PhD in Bioinformatics and Systems Biology from UCSD. My doctoral dissertation involved characterizing the regulatory genetics of the adrenaline-synthesis gene PNMT, as well as more broadly studying the human adrenergic stress pathway. Seeking additional training in genomics and statistics, I spent a year working with Kelly Frazer at the Moores UCSD Cancer Center, followed by a move to Weill Cornell Medical College in 2010.
As a postdoc, I developed a set of genomic analysis skills and tools that I applied to numerous projects, both locally and with international collaborators such as the 1000 Genomes Project, Weill Cornell Medical School in Qatar, and the University of Puerto Rico.
As an Instructor in the Department of Genetic Medicine at Weill Cornell Medical College, I worked on the analysis of next generation sequencing data of genomes, exomes, transcriptomes, and epigenomes. In addition to research, I served as one of the Unit Leaders for the Genetics Unit of the first-year medical student Essential Principles of Medicine Course. This 3-week course was developed from scratch, and includes lectures by myself and other experts in genetics and genomics at Weill Cornell.
In my new appointment as Assistant Professor, I am tasked with developing biotechnology tools for precision medicine.
Publications
Funding
Completed grants (5)
- Co-IPPM3-0314-190024Precision Pharmacogenomics in QatarQatar National Research Fund · 2020–2023 · via Weill Cornell Medical College/Qatar
- KPPPM 03-0314-190024Precision Pharmacogenomics in QatarQatar National Research Fund · 2020–2022
- MPINPRP8-1913-3-396Design and Implementation of the First Qatari Population-Centric High-Throughput Custom-Genotyping Microarray, With an Accompanying Private Qatari Genome BrowserQatar National Research Fund · 2016–2020 · via Weill Cornell Medical College/Qatar
- MPINPRP 7-701-3-192DNA Methylation and Gene Expression in Qataris With Type 2 DiabetesQatar National Research Fund · 2015–2018 · via Weill Cornell Medical College/Qatar
- KPNPRP 7-1301-3-336Identification and Characterization of Bone-Related Genetic Variants in FamiliesQatar National Research Fund · 2015–2018 · via Hamad Medical Corporation
News mentions
- Qatar Project Highlights the Importance of Population-Specific Genetic Screening Tools for Personalized MedicineJanuary 19, 2022
A team led by collaborating researchers from Weill Cornell Medicine, Weill Cornell Medicine—Qatar and Qatar Foundation have assembled a large genomic database on the Qatari people, and have used it to develop an advanced but low-cost screening tool for genetic diseases in this highly distinct Middle Eastern population.
- Decoding DNA: Researchers in Doha and New York Collaborate to Explore the Qatari GenomeOctober 10, 2019
Researchers in Doha and New York are collaborating to explore the Qatari genome.
External relationships
Other
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