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Overview

Honghai Liu is an Assistant Professor of Bioengineering in Pediatrics at Weill Cornell Medicine. His research focuses on how heart muscle cells (cardiomyocytes) divide and mature, questions that are central to understanding heart development and advancing cardiac regeneration. He develops and introduces cutting-edge biomedical technologies into the field of cardiac regeneration, with the long-term goal of developing translational strategies for patients with congenital heart disease, particularly Tetralogy of Fallot (ToF). Liu’s current research focuses on how calcium signaling regulates cardiomyocyte cell-cycle activity and division, the genes and molecular mechanisms involved in the development of ToF, and the mechanisms underlying late-onset heart failure in patients with repaired ToF. Liu holds a Ph.D. in Bioengineering from Clemson University and a Ph.D. in Materials Physics and Chemistry from Tianjin University in China.

Highlights

  1. 1
    The Journal of cell biology · 2026
    PMID: 42347846PMCID: PMC13308196DOIFirst author
  2. 2
    Science translational medicine · 2019
    PMID: 31597755PMCID: PMC8132604DOIFirst author106 citations
  3. 3
    Nature protocols · 2021
    PMID: 33627842PMCID: PMC8221415DOI13 citations

Publications

14 publications

Funding

2 grants

Active

2 grants
  • Co-I
    Endothelin-1 inhibits cardiomyocyte proliferation and heart regeneration
    National Heart, Lung, and Blood Institute · 2026–2030
    R01HL188510-01
  • Co-I
    Mechanistic clinical trial of Beta-blocker administration for reactivating cardiomyocyte division in Tetralogy of Fallot
    National Heart, Lung, and Blood Institute · 2024–2027
    R01HL155597-04