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Overview

Harold Varmus, M.D., co-recipient of the Nobel Prize for studies of the genetic basis of cancer, joined the Meyer Cancer Center of Weill Cornell Medicine as the Lewis Thomas University Professor of Medicine on April 1, 2015. Prior to joining Meyer Cancer Center, Dr. Varmus was the Director of the National Cancer Institute for five years. He was also the President of Memorial Sloan-Kettering Cancer Center for 10 years and Director of the National Institutes of Health for six years. A graduate of Amherst College and Harvard University in English literature and Columbia University in Medicine, he trained at Columbia University Medical Center, the National Institutes of Health, and the University of California San Francisco (UCSF), before becoming a member of the UCSF basic science faculty for over two decades. He is a member of the U.S. National Academy of Sciences and the Institute of Medicine and is involved in several initiatives to promote science and health in developing countries. The author of over 350 scientific papers and five books, including a recent memoir titled The Art and Politics of Science, he was a co-chair of President Obama’s Council of Advisors on Science and Technology, a co-founder and Chairman of the Board of the Public Library of Science, and chair of the Scientific Board of the Gates Foundation Grand Challenges in Global Health.

Highlights

  1. 1
    Science (New York, N.Y.) · 2024
    PMID: 38330136PMCID: PMC11155264DOISenior author101 citations
  2. 2
    Proceedings of the National Academy of Sciences of the United States of America · 2024
    PMID: 38743625PMCID: PMC11127050DOISenior author7 citations
  3. 3
    Science (New York, N.Y.) · 2021
    PMID: 33833113DOISenior author44 citations

Publications

447 publications
Completed grants (16)
  • PI
    Studies of the initiation and progression of small cell lung cancer using cells derived by differentiation from human pluripotent stem cells
    National Cancer Institute · 2018–2025· 2 renewals
    U01CA224326-05
  • KP
    Weill Cornell Medicine (WCM) SPORE in Prostate Cancer
    National Cancer Institute · 2017–2023
    P50CA211024-05
  • PI
    Addgene 704897
    Addgene, Inc. · 2022–2023
    Addgene 704897
  • KP
    Interrogating Lung Adenocarcinoma Transformation to Small Cell Lung Cancer at Single Cell Resolution
    Damon Runyon Cancer Research Foundation · 2018–2022Fellowship
    DRG 2344-18
  • MPI
    Seeking and Evaluating Novel Therapeutic Targets in Human Lung Adenocarcinomas with Loss-of-Function Mutations in LKB1
    Damon Runyon Cancer Research Foundation · 2018–2022
    18-18
  • KP
    Investigation of sub-lineages in pulmonary neuroendocrine cells and identification of the cells of origin of small cell lung cancer
    National Cancer Institute · 2019–2020
    K99CA226353-01A1
  • PI
    The Roles of Mutant U2AF1 in the Initiation and Maintenance of MDS
    Edward P. Evans Foundation · 2018–2019
    DRG 2017
  • PI
    Using HESC-Derived Lung Cells to Study the Initiation of Small Cell Lung Cancer
    U.S. Department of Defense · 2017–2019
    W81XWH-17-1-0223
  • PI
    The Roles of Mutant U2AF1 in the Initiation and Maintenance of MDS2
    Edward P. Evans Foundation · 2017–2018
    DRG 2017
  • KP
    Identify Synthetic Lethality Targeting APC - or KRAS - Mutations in Organotypic Human Colorectal Cancer Models
    Arnold & Mabel Beckman Foundation · 2016–2018
    AMBF 180582-03
  • MPI
    Mouse Models for Tumor Progression and Maintenance
    NCI · 2008–2013 · via NIH RePORTER
    P01CA094060-07
  • MPI
    PLANNING and EVALUATION
    NCI · 1977–2012 · via NIH RePORTER
    P30CA008748-46
  • MPI
    Targeting EGFR and KRAS Mutations
    NCI · 2007–2012 · via NIH RePORTER
    P01CA129243-05
  • MPI
    STUDYING EGFR INTERACTING PARTNERS
    NCRR · 2008–2012 · via NIH RePORTER
    P41RR000862-38
  • PI
    Mutant EGF Receptor-Dependent Lung Cancer in Human Cell Lines and Transgenic Mice
    NCI · 2006–2010 · via NIH RePORTER
    R01CA120247-03
  • MPI
    Tumor maintenance and development in mouse models
    NCI · 2004–2009 · via NIH RePORTER
    U01CA105492-05

Honors & distinctions

6 honors
  • National Medal of Science · National Science Foundation · 2001
  • Member · National Academy of Medicine · 1991
  • Nobel Prize in Physiology or Medicine · Nobel Foundation · 1989
  • Fellow · American Academy of Arts and Sciences · 1988
  • Member · National Academy of Sciences · 1984
  • Albert Lasker Basic Medical Research Award · Lasker Foundation · 1982

Available technologies

News mentions

  • How One Type of Lung Cancer Can Transform into Another
    February 8, 2024

    Researchers at Weill Cornell Medicine have uncovered steps that lead to lung tumors called adenocarcinoma turning into a much more aggressive small cell lung cancer that spreads rapidly and has few options for treatment. This problematic process is sometimes seen when patients stop responding to initially effective treatments. The findings advance the understanding of how mutated genes can trigger cancer evolution and suggest targets for more effective treatments.

  • Awards and Honors Across Weill Cornell Medicine - March 31, 2021
    March 31, 2021

    Awards, honors, prizes and achievements for the month of March.