Guillaume has a strong interest in clinical simulation-based education, patient safety, and human factors and has held senior positions with various healthcare simulation societies. He is regularly involved in educational simulation activities in various medical specialties and contributes to the planning and running of single and multi-agency full-scale and table top major incident simulation exercises. He has been affiliated with the field of pre-hospital care since the beginning of his academic career nearly 20 years ago. He serves on 7 peer reviewed journal editorial boards and has published widely, including 2 books on debriefing.
Some of his other recent work has been on ECMO education and simulation education, accreditation, and certification.