David Artis, PhD

Overview

Description of Research Expertise \t The goals of the Artis lab are to understand the regulatory mechanisms that control immune cell homeostasis at the body’s barrier surfaces. Employing diverse models of microbial colonization, pathogen infection and chronic inflammation, research in the Artis lab is examining how mammalian host genetics and signals derived from commensal microbial communities influence innate and adaptive immune responses in the skin, lung and intestine.

Studies from a number of labs including the Artis lab, have highlighted that differential colonization of the body’s barrier surfaces by defined commensal bacterial communities can have a profound effect on the development and function of distinct T helper cell populations including Th1, Th2, Th17 and regulatory T cells (Tregs). Dysregulation in the balance of these helper T cell populations can profoundly alter susceptibility to a number of chronic inflammatory diseases including allergy, asthma, arthritis, multiple sclerosis, psoriasis and inflammatory bowel disease. Research in the Artis lab is focusing on how host factors including expression of cytokines and cytokine receptors can influence the balance of helper T cell responses and the development of chronic inflammation.

Recent studies in the Artis lab indicate that innate lymphoid cells, an emerging population of innate cells that express proinflammatory cytokines, may also contribute to the pathogenesis of multiple chronic inflammatory diseases. Innate lymphoid cells are derived from a common Id2-dependent precursor and appear to influence immunity, inflammation and tissue repair and homeostasis in health and disease. Ongoing studies are examining the influence of host- and environmental-derived signals on the development and functions of innate lymphoid cells. The findings of these studies offer the potential to identify new therapeutic targets to limit infection, chronic inflammation and autoimmune diseases.

Highlights

1
Nature · 2022
MAMohammad Arifuzzaman AHAndrea Heras CPChristopher Parkhurst SKSangeeta Kashyap+2 more →DADavid Artis
PMID: 36323778PMCID: PMC10576985DOISenior author232 citations
2
Nature · 2022
CPChristopher Parkhurst ILIvo Lorenz DADavid Artis
PMID: 36323781PMCID: PMC10225046DOISenior author131 citations
3
Cell · 2022
MAMohammad Arifuzzaman CPChristopher Parkhurst JZJordan Zhou CGChun-Jun Guo DADavid Artis
PMID: 36240781PMCID: PMC9617796DOISenior author170 citations

Publications

228

Funding

48 View NIH portfolio on RePORTER ↗

Active

20 grants

PI
A neuro-immune circuit regulates helminth-induced type 2 inflammation
NIAID · 2026–2031 · via NIH RePORTER
R01AI196067-01A1
MPI
Caloric restriction to enhance cancer immunoprevention
National Cancer Institute · 2026–2031
R01CA311885-01
PI
Identification of Enteric Neuroimmunue Mechanisms in Vedolizumab Response in IBD Patients, and by Extension to Other HI Diseases for Target Identification
Millennium Pharmaceuticals, Inc. · 2019–2031BioPharma Alliance
BP 194547-01
Co-I
The role of microbiota amino acid metabolism in cancer
National Cancer Institute · 2025–2030
R01CA299862-01
Co-I
PICI Grant and Main Collaboration Agreement with Multiple Subprojects
Parker Institute for Cancer Immunotherapy · 2024–2028
PICI 235170-03
KP
Adaptive Immune Regulation of Enteric Neurogenesis Directs Intestinal Inflammation
National Institute of Diabetes and Digestive and Kidney Diseases · 2026–2028Career
K99DK147794-01
PI
Microbiota-derived metabolites and the regulation of host immunity and inflammation
National Institute of Allergy and Infectious Diseases · 2022–2027· 2 renewals
R01AI172027-03S1
MPI
Dietary Regulation of Intestinal Inflammation and Repair
National Institute of Diabetes and Digestive and Kidney Diseases · 2022–2027
R01DK132244-04
KP
Dietary regulation of type 2 immunity and inflammation in the gut
National Institute of Allergy and Infectious Diseases · 2025–2026
R00AI173660-03
KP
Neuro-immune regulation of inter-organ skin-gut inflammation
National Institute of Allergy and Infectious Diseases · 2024–2026
K99AI180354-01A1
KP
Microbial Regulation of Microglial Function
National Institute of Mental Health · 2022–2026Career
K08MH130773-04
KP
Enteric glia cell regulation of intestinal inflammation and tissue protection
Crohn's and Colitis Foundation of America · 2025–2026
1455492
PI
Neuro-immune regulation of intestinal inflammation
National Institute of Diabetes and Digestive and Kidney Diseases · 2020–2026
R01DK126871-05
MPI
MIST Early Career Scholar Awards in Mucosal Immunology
National Institute of Allergy and Infectious Diseases · 2015–2026· 5 renewals
U01AI095608-16S1
Sub-PI
Sensing Tissue Homeostasis in Health and Disease
Paul G. Allen Family Foundation · 2023–2026 · via Icahn School of Medicine at Mount Sinai
202205-13295
KP
Neuro-immune regulation of intestinal inflammation and tissue protection in IBD
Crohn's and Colitis Foundation of America · 2022–2026
CCFA 937437
Sub-PI
Neuroimmune Regulation of Atopic Dermatitis
National Inst of Arthritis & Musculoskeletal & Skin Diseases · 2022–2026 · via Icahn School of Medicine at Mount Sinai
R01AR070116-07
KP
Adrenomedullin 2 Regulates ILC2 Responses to Control Intestinal Inflammation
National Institute of Diabetes and Digestive and Kidney Diseases · 2025–2026Fellowship
F32DK139586-01A1
KP
Nociceptor regulation of intestinal inflammation and tissue protection
National Institute of Diabetes and Digestive and Kidney Diseases · 2024–2026
K99DK138295-01A1
KP
Investigating the role of the microbiota in enhancing memory T cell function during caloric restriction to promote melanoma control
National Cancer Institute · 2022–2026
R00CA252443-02

Completed grants (28)

Sub-PI
Neuropeptide-mediated regulation of antihelminth immunity
National Institute of Allergy and Infectious Diseases · 2020–2025 · via Rutgers, The State University of New Jersey – New Brunswick
R01AI151599-05
KP
Sensory neuronal regulation of intestinal health and disease
Crohn's and Colitis Foundation of America · 2022–2024
CCFA 901000
KP
Influence of Diet and Microbiota on Intestinal Inflammation and Repair
Crohn's and Colitis Foundation of America · 2021–2024
CCFA #851136
PI
Regulation and Function of Innate Lymphoid Cells in the Gut
National Institute of Allergy and Infectious Diseases · 2014–2024· 2 renewals
R01AI095466-10
PI
Addgene 701281
Addgene, Inc. · 2022–2023
Addgene 701281
PI
Microbiota-dependent regulation of the gut-brain axis
National Institute of Allergy and Infectious Diseases · 2019–2022
R21AI142213-02
KP
The gut-brain axis in fear extinction
Brain & Behavior Research Foundation · 2021–2022
BBRF 203622-01
Co-I
Regulation of the mycobiota and intestinal inflammation via production of antifungal metabolites by commensal bacteria
National Institute of Diabetes and Digestive and Kidney Diseases · 2019–2022Fellowship
F32DK120228-01
MPI
Mucosal Immune Defense Mechanisms of the Urinary Bladder
National Institute of Allergy and Infectious Diseases · 2018–2021 · via Washington University, The· 3 renewals
U01AI095542-10
Co-I
Regulation of immunity by calcitonin gene-related peptide through effects on endothelial cells.
LEO Foundation · 2017–2021
LF 180675-02
PI
Innate Immunity and Inflammation Following Helminth Infection
National Institute on Aging · 2014–2020
R01AI074878-10
KP
Role of Arginase Metabolism in Innate Lympohid Cell-Mediated Lung Inflammation-Senior Research Fellowship
American Lung Association, Incorporated · 2018–2020Fellowship
RT- 571123
KP
Elucidating the Role of the Microbiome in Inflammatory Bowel Disease
Crohn's and Colitis Foundation of America · 2017–2020
CCF 527125
KP
Instrumentation for Ultra-High Resolution MALDI-FT-ICR Imaging Core
Office of the Director, NIH · 2017–2020Equipment
S10OD023652-01
PI
Regulation and Function of Innate Lymphoid Cells During Influenza Virus Infection
National Institute of Allergy and Infectious Diseases · 2014–2019
R01AI102942-03
PI
NYC IBD Research Day 2019
Regeneron Pharmaceuticals · 2019–2019
RP 194491-01
PI
NYC Inflammatory Bowel Disease Research Day 2018
Janssen Research & Development, LLC · 2018–2019Contract
JRD 190162-01
PI
Epigenetic Regulation of IBD
Crohn's and Colitis Foundation of America · 2014–2019
CCFA 183379-04
PI
Cytokine Regulation of Anti-Helminth Immunity
National Institute of Allergy and Infectious Diseases · 2014–2019
R01AI097333-04
KP
ß2AR Regulation of WAT ILC2-Mediated Metabolic Homeostasis
National Institute of Diabetes and Digestive and Kidney Diseases · 2016–2019Fellowship
F32DK109630-03
PI
Regeneron Research Conference Funding RD-6175
Regeneron Pharmaceuticals · 2018–2018Contract
RPI 190742-01
Sub-PI
Tissue Compartmentalization of Human Lymphocytes
National Institute of Allergy and Infectious Diseases · 2014–2018 · via Columbia University
P01AI106697-05
Sub-PI
CCFA Genetics Initiative Pilot Feasibility Study: Xenophagy Defects in Patients With Monogenic Inflammatory Bowel Disease
Crohn's and Colitis Foundation of America · 2015–2018 · via The General Hospital Corporation (dba Massachusetts General Hospital)
MGH 3765 EWOF
PI
The 4th Annual Meeting of the International Cytokine and Interferon Society (ICIS)
National Institute of Allergy and Infectious Diseases · 2016–2017
R13AI126789-01
MPI
Human MAIT Cells in Airway Mucosal Immune Responses to Intracellular Infections
National Institute of Allergy and Infectious Diseases · 2015–2016 · via Oregon Health & Science University
U01AI095776-05
PI
Immuno-Regulation of GI Nematode Infection
National Institute of Allergy and Infectious Diseases · 2014–2016
R01AI061570-11EWO
PI
Functional Biology of Intestinal Epithelial Cells in Food Allergy
NIAID · 2010–2013 · via NIH RePORTER
R21AI087990-02
PI
Epithelial cell regulation of intestinal immune homeostasis
NIAID · 2009–2012 · via NIH RePORTER
R21AI083480-02

Available technologies

2 View full WCM portfolio ↗

News mentions

20 View all WCM news ↗

Gut Bacteria May Tip the Balance between Feeding Tumors and Fueling Immunity
January 29, 2026
A new study reveals how bacteria in the gut can help determine whether the amino acid asparagine from the diet will feed tumor growth or activate immune cells against the cancer, according to researchers at Weill Cornell Medicine.
Pain-Sensing Neurons Kick-Start Immune Responses
January 7, 2026
Pain-sensing neurons in the gut kindle inflammatory immune responses that cause allergies and asthma, according to a new study by Weill Cornell Medicine.
Gut Neurons Help the Body Fight Inflammation
August 15, 2025
Neurons in the gut produce a molecule that plays a pivotal role in shaping the gut’s immune response during and after inflammation, according to a new study by Weill Cornell Medicine investigators.
Gut Microbes Release Cancer-fighting Bile Acids that Block Hormone Signals
April 15, 2025
Bacteria naturally present in the human intestine, known as the gut microbiota, can transform cholesterol-derived bile acids into powerful metabolites that strengthen anti-cancer immunity by blocking androgen signaling, according to a preclinical study led by Weill Cornell Medicine investigators.
Diet, Microbes and Fat: A New Pathway Controlling Levels of Body Fat and Cholesterol
January 8, 2025
Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study.

Show 15 more mentions

Dr. Mohammad Arifuzzaman Wins 2024 Tri-Institutional Breakout Award
June 14, 2024
Dr. Mohammad Arifuzzaman, a postdoctoral associate at Weill Cornell Medicine, has been awarded a 2024 Tri-Institutional Breakout Award for Junior Investigators.
Common Type of Fiber May Trigger Bowel Inflammation
May 2, 2024
Inulin, a type of fiber found in certain plant-based foods and fiber supplements, causes inflammation in the gut and exacerbates inflammatory bowel disease in a preclinical model, according to a new study by Weill Cornell Medicine investigators.
New Consortium Aims to Transform Understanding of How the Human Body Senses Health and Disease
November 9, 2023
Co-led by Dr. David Artis at Weill Cornell Medicine, the Allen Discovery Center for Neuroimmune Interactions at the Icahn School of Medicine at Mount Sinai hopes to revolutionize the field of medicine with a groundbreaking project to understand how the human body senses health and disease.
A Common Dietary Fiber Promotes Allergy-Like Immune Responses in Preclinical Studies
November 2, 2022
A type of dietary fiber called inulin, commonly used in health supplements and known to have certain anti-inflammatory properties, can also promote an allergy-related type of inflammation in the lung and gut, and other parts of the body.
Study Offers Insight into Immune Mechanisms of Inflammatory Disease
November 2, 2022
Innate lymphoid cells are a recently discovered family of white blood cells that reside in the skin, gastrointestinal tract, airways and other barrier tissues of the body. Group 2 innate lymphoid cells (ILC2s) have an essential role in protecting these tissues from parasitic infections as well as damage associated with allergic inflammation and asthma, according to a new study led by Weill Cornell Medicine researchers.
Pain-Sensing Gut Neurons Protect Against Inflammation
October 14, 2022
Neurons that sense pain protect the gut from inflammation and associated tissue damage by regulating the microbial community living in the intestines, according to a study from researchers at Weill Cornell Medicine.
Awards Recognize Faculty and Student Achievements
May 26, 2022
Weill Cornell Medicine faculty members were honored with awards for their exemplary achievements in medical research, education and care at the institution’s commencement ceremony on May 19 at Carnegie Hall.
Awards and Honors – April 29, 2022
April 29, 2022
Awards, honors, prizes and achievements for the month of April.
Study Recruiting 1,000 Healthcare Workers to Investigate Underlying Factors Driving COVID-19 Outcomes
October 6, 2020
A study by investigators at Weill Cornell Medicine and NewYork-Presbyterian aims to answer one of COVID-19’s biggest mysteries: why do some people become severely ill, while others have no symptoms?
Fungus in Gut May Explain Why Some Ulcerative Colitis Patients Benefit from Fecal Transplant
May 14, 2020
Higher levels of a type of fungus in the gut are associated with better outcomes for patients with a type of inflammatory bowel disease called ulcerative colitis who are treated with gut microbes from healthy donors.
Scientists Identify New Pathways to Inflammation in Allergy-Linked Immune Cells
April 30, 2020
A class of immune cells push themselves into an inflammatory state by producing large quantities of a serotonin-making enzyme, according to a study in mice led by scientists at Weill Cornell Medicine.
Gut Instincts: Researchers Discover First Clues on How Gut Health Influences Brain Health
October 23, 2019
New cellular and molecular processes underlying communication between gut microbes and brain cells have been described for the first time by scientists at Weill Cornell Medicine and Cornell’s Ithaca campus.
Discovery May Open Up New Possibilities for Treating Allergic Inflammatory Diseases
July 25, 2019
A molecule best known for its association with migraines may be a key to new treatments for common worm infections as well as allergic inflammatory disorders such as asthma, according to a study from scientists at Weill Cornell Medicine and the National Institutes of Health.
Discovery Reveals Potential New Pathway for Treating Obesity and Related Disorders
May 3, 2019
A molecule that helps prevent fat accumulation in mammals is produced within fat tissues by stem-like cells that may be therapeutic targets for obesity and related disorders.
Researchers Create the First Anatomical Map of Innate Lymphoid Cells in Healthy Human Tissues
February 12, 2019
Researchers have long known that dysfunction in the body’s innate immune system breaks the first line of defense against invading pathogens, enabling diseases to flourish unchecked.