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ScholarsBetaWeill Cornell Medicine

Overview

Understanding the unique workings of heart muscle cells - cardiomyocytes - is the passion of physician-scientist Bernhard Kühn. He and his team of researchers are focused on discovering ways to make cardiomyocytes replicate and proliferate, so as to enable the heart to heal itself in cases of heart failure or congenital defects.

Highlights

  1. 1
    Developmental cell · 2020
    BKBernhard Kuhn
    PMID: 32109383PMCID: PMC7346764DOISenior author80 citations
  2. 2
    Developmental cell · 2022
    HLHonghai LiuBKBernhard Kuhn
    PMID: 36283391PMCID: PMC9614572DOISenior author23 citations
  3. 3
    Development (Cambridge, England) · 2021
    HLHonghai LiuBKBernhard Kuhn
    PMID: 34897388PMCID: PMC8326922DOISenior author37 citations

Publications

47 publications

Funding

6 grantsView NIH portfolio on RePORTER ↗

Active

3 grants
  • PI
    Endothelin-1 inhibits cardiomyocyte proliferation and heart regeneration
    National Heart, Lung, and Blood Institute · 2026–2030
    R01HL188510-01
  • PI
    Mechanistic clinical trial of Beta-blocker administration for reactivating cardiomyocyte division in Tetralogy of Fallot
    National Heart, Lung, and Blood Institute · 2024–2027· 2 renewals
    R01HL155597-04
  • PI
    Quantification of the decline of heart muscle cell proliferation and its reversal in pediatric patients
    National Heart, Lung, and Blood Institute · 2024–2026
    R01HL151386-05
Completed grants (3)
  • PI
    Lamin B2 regulates nuclear remodeling in cardiomyocyte terminal differentiation
    National Heart, Lung, and Blood Institute · 2024–2025
    R01HL151415-05
  • PI
    Myofibril disassembly during neonatal heart muscle cell proliferation
    NHLBI · 2010–2016 · via NIH RePORTER
    R01HL106302-05
  • PI
    Periostin in Myocardial Injury and Regeneration
    NHLBI · 2009–2014 · via NIH RePORTER
    K08HL085143-05

Honors & distinctions

1 honor
  • Member · American Society for Clinical Investigation

Clinical research

2 studies

Active

2 studies
  • PI
    A Pilot Study for Quantifying New Heart Muscle Cells
    NA · Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2025)
    Tetralogy of Fallot With Pulmonary Stenosis; Heart Failure
    NCT06587165
  • PI
    Mechanistic Clinical Trial of Beta-Blocker Administration For Reactivating Cardiomyocyte Division In Tetralogy of Fallot
    PHASE1 · Weill Medical College of Cornell University · OPEN TO ACCRUAL (as of 2024)
    Tetralogy of Fallot; Double Outlet Right Ventricle
    NCT04713657

News mentions

1 mentionView all WCM news ↗

Mentoring

1 mentee