Overview

1. 1
   Regenerative lineages and immune-mediated pruning in lung cancer metastasis.

   Nature medicine · 2020

   ALAshley LaughneyCRCharles Rudin

   PMID: 32042191·PMCID: PMC7021003·DOI·First author·377 citations·Abstract
2. 2
   Loss of polycomb repressive complex 1 activity and chromosomal instability drive uveal melanoma progression.

   Nature communications · 2021

   JHJasmine H. FrancisEEEthan EarlieALAshley Laughney

   PMID: 34518527·PMCID: PMC8438051·DOI·Senior author·48 citations·Abstract

• PI

  A systems-level approach to therapeutically target STING in cancer

  National Cancer Institute · 2025–2030

  Abstract

  R01CA282762-02
• KP

  Using generative modeling to understand heterogeneous patterns of cellular communication from scRNA-seq data

  National Science Foundation · 2025–2028

  NSF 231527-01
• PI

  Dissecting the impact of tumor-intrinsic chromosomal instability on the cancer ecosystem

  National Cancer Institute · 2023–2028

  Abstract & 5 publications

  R01CA280572-04
• Sub-PI

  Multi-cellular interactions defining the human brain metastatic niche

  National Cancer Institute · 2023–2028 · via Columbia University

  Abstract & 6 publications

  R01CA280414-04
• Co-I

  "Novel Mouse Models for Quantitative Understanding of Baseline and Therapy-Driven Evolution of Prostate Cancer Metastasis"

  National Cancer Institute · 2023–2028

  Abstract

  R01CA272466-01A1
• PI

  Dissecting the Role of Micronuclei in Tumor Evolution

  Pershing Square Foundation · 2025–2027

  PSF 253389-01
• PI

  SatSeq: a scalable platform to effectively target multi-modal proteins in cancer

  Pershing Square Sohn Cancer Research Alliance · 2024–2027

  PQSC 243031-01
• PI

  Uncovering transcriptional vulnerabilities in latent metastasis

  Burroughs Wellcome Fund · 2019–2027

  BWF 1015818.01
• PI

  Probing cytosolic nucleic acid sensing pathways in cancer

  National Cancer Institute · 2021–2026

  Abstract & 8 publications

  R01CA256188-05
• Co-I

  Targeting immune evasion in gastroesophageal cancer

  Stand Up To Cancer · 2023–2026 · via Memorial Sloan Kettering Cancer Center

  SU2C 6352
• Sub-PI

  Dissecting the Role of Micronuclei in Tumor Evolution

  Pershing Square Foundation · 2025–2026 · via Memorial Sloan Kettering Cancer Center

  MSK 260903-01

• Dr. Ashley Laughney Wins Pershing Square Sohn Prize for Young Investigators in Cancer Research

  June 17, 2024

  Dr. Ashley Laughney, an assistant professor of physiology and biophysics at Weill Cornell Medicine, has won a 2024 Pershing Square Sohn Prize for Young Investigators in Cancer Research.

• How One Type of Lung Cancer Can Transform into Another

  February 8, 2024

  Researchers at Weill Cornell Medicine have uncovered steps that lead to lung tumors called adenocarcinoma turning into a much more aggressive small cell lung cancer that spreads rapidly and has few options for treatment. This problematic process is sometimes seen when patients stop responding to initially effective treatments. The findings advance the understanding of how mutated genes can trigger cancer evolution and suggest targets for more effective treatments.

• New Research Shows How Cancer Rewires a Key Immune Pathway To Spread

  August 23, 2023

  A study led by researchers at Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine discovered a new relationship between cancer cells and the immune system, and shows how cancer can selfishly hijack a normally helpful immune pathway.