Overview
Assistant Professor of Medicine
Principal Investigator of Phase II Consortium/NCI and Cooperative Group Trials NCI Protocol # 6490. A Phase II Study of FOLFOX6, Bevacizumab, and Cetuximab in Colorectal Cancer. NCI Protocol # 5941. A Phase II Study of PS-341 alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction (GEJ) or stomach. NCI Protocol # 6580. A Randomized Phase II Study of Bevacizumab (NSC# 704865) and Gemcitabine in Combination with Either Cetuximab (NSC# 714692) or OSI-774 (NSC# 718781) in Patients with Advanced Pancreatic Cancer. NCI Protocol # 6254. A Phase II Study of Triapine in Combination with Gemcitabine in Adenocarcinoma of the Biliary Ducts and Gall Bladder. NCI Protocol # 6335. A Phase II Study of Single Agent Depsipeptide in Patients with Unresctable Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck CALGB 80402. Phase II Trial of LE-SN38 in Patients with Metastatic Colorectal Cancer after Progression on Oxaliplatin. CALGB 80101. A Phase III Trial of Adjuvant Chemoradiation after Resection of Gastric and Gastroesophageal Adenocarcinoma ECOG 5204. Intergroup Randomized Phase III Study of Prospective Oxaliplatin, 5-Fluorouracil and Leucovorin vs Oxaliplatin, 5-Fluorouracil, Leucovorin and Bevacizumab for Patients with Stage II or III Rectal Cancer Receiving Pre-operative Chemoradiation. NSABP-C08. A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks with Bevacizumab to the Same Regimen without Bevacizumab for the Treatment of Patients with Resected Stages II and III Carcinoma of the Colon. Principal Investigator at Weill Cornell Medical College- Industry Sponsored Trials Astra Zeneca. A Phase II, Open, Randomised Study to Assess the Efficacy and Safety of AZD6244 vs. capecitabine (XelodaTM) in Patients with Advanced or Metastatic Pancreatic Cancer, who have Failed First Line Gemcitabine Therapy (GemzarTM) Astra Zeneca. A Phase II, double-blind, placebo controlled, randomized study to assess the efficacy and safety of 2 doses of ZACTIMA (ZD6474) in combination with FOLFIRI vs. FOLFIRI alone for the treatment of colorectal cancer in patients who have failed therapy with an oxaliplatin and fluoropyrimidine-containing regimen
Highlights
- 1Annals of oncology : official journal of the European Society for Medical Oncology · 2021
- 2
- 3
Publications
Funding
Completed grants (2)
- Sub-PIR44CA165312-03 EWDevelopment of a Urine Test for the Early Detection of Liver CancerNational Cancer Institute · 2015–2016 · via JBS Sciences
- MPIM01RR000047-47PHASE II TRIAL OF FOLFOX6, BEVACIZUMAB AND CETUXIMAB IN PATIENTSNCRR · 2006–2007 · via NIH RePORTER
Clinical research
Active
1 study- PINCT04172532A Phase 1/2 Study of M3814 (Peposertib) in Combination With Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic AdenocarcinomaPHASE1; PHASE2 · National Cancer Institute · OPEN TO ACCRUAL (as of 2024)Locally Advanced Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8
Completed & closed trials (6)
- PINCT05630183A Randomized, Open-Label, Phase II Trial of Nab-paclitaxel + Gemcitabine With or Without Botensilimab (AGEN1181) in Patients With Metastatic Pancreatic Cancer Who Have Progressed on Prior 5FU + Leucovorin + Irinotecan + Oxaliplatin (FOLFIRINOX)PHASE2 · Agenus Inc · IRB STUDY CLOSURE (as of 2026)Metastatic Pancreatic Ductal Adenocarcinoma
- PICompassionate Use of Botensilimab (AGEN1181) in Combination with nab-Paclitaxel and Gemcitabine for Treatment of Pancreatic Cancer in Patient L-TWeill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2025)
- PINCT05673148A Pragmatic Randomized Phase II Trial Evaluating Total Ablative Therapy for Patients With Limited Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery (ERASur)PHASE2 · Alliance for Clinical Trials in Oncology · CLOSED TO ACCRUAL (as of 2025)Metastatic Colorectal Adenocarcinoma; Stage IV Colorectal Cancer AJCC v8; Oligometastatic Colorectal Carcinoma
- PICompassionate Use of Botensilimab (AGEN1181) in Combination with nab-Paclitaxel and Gemcitabine for Treatment of Pancreatic Cancer in Patient C-HWeill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2024)
- PISingle-Patient IDE for Use of NovoTTF-200T Device in Patient N-SWeill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2024)
- PISingle-Patient IDE for Use of NovoTTF-200T Device in Patient S-BWeill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2024)
External relationships
Leadership Roles
American Jewish Medical Association · Novocure, Inc. · Oceans of Blessings · The Jack and Jill Late Stage Cancer Foundation · The POLG Foundation
Ownership
Let's Win Pancreatic Cancer · Novocure, Inc.
Advisory/Scientific Board Member
FORCE-Facing Our Risk of Cancer Empowered INC · Let's Win Pancreatic Cancer · Revolution Medicines, Inc. · Stephenson Global Pancreatic Cancer Research Institute
Other
Natera, Inc.