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Overview

Assistant Professor of Medicine

Principal Investigator of Phase II Consortium/NCI and Cooperative Group Trials NCI Protocol # 6490. A Phase II Study of FOLFOX6, Bevacizumab, and Cetuximab in Colorectal Cancer. NCI Protocol # 5941. A Phase II Study of PS-341 alone or in combination with irinotecan in patients with adenocarcinoma of the gastroesophageal junction (GEJ) or stomach. NCI Protocol # 6580. A Randomized Phase II Study of Bevacizumab (NSC# 704865) and Gemcitabine in Combination with Either Cetuximab (NSC# 714692) or OSI-774 (NSC# 718781) in Patients with Advanced Pancreatic Cancer. NCI Protocol # 6254. A Phase II Study of Triapine in Combination with Gemcitabine in Adenocarcinoma of the Biliary Ducts and Gall Bladder. NCI Protocol # 6335. A Phase II Study of Single Agent Depsipeptide in Patients with Unresctable Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck CALGB 80402. Phase II Trial of LE-SN38 in Patients with Metastatic Colorectal Cancer after Progression on Oxaliplatin. CALGB 80101. A Phase III Trial of Adjuvant Chemoradiation after Resection of Gastric and Gastroesophageal Adenocarcinoma ECOG 5204. Intergroup Randomized Phase III Study of Prospective Oxaliplatin, 5-Fluorouracil and Leucovorin vs Oxaliplatin, 5-Fluorouracil, Leucovorin and Bevacizumab for Patients with Stage II or III Rectal Cancer Receiving Pre-operative Chemoradiation. NSABP-C08. A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU), Leucovorin, and Oxaliplatin (mFOLFOX6) Every Two Weeks with Bevacizumab to the Same Regimen without Bevacizumab for the Treatment of Patients with Resected Stages II and III Carcinoma of the Colon. Principal Investigator at Weill Cornell Medical College- Industry Sponsored Trials Astra Zeneca. A Phase II, Open, Randomised Study to Assess the Efficacy and Safety of AZD6244 vs. capecitabine (XelodaTM) in Patients with Advanced or Metastatic Pancreatic Cancer, who have Failed First Line Gemcitabine Therapy (GemzarTM) Astra Zeneca. A Phase II, double-blind, placebo controlled, randomized study to assess the efficacy and safety of 2 doses of ZACTIMA (ZD6474) in combination with FOLFIRI vs. FOLFIRI alone for the treatment of colorectal cancer in patients who have failed therapy with an oxaliplatin and fluoropyrimidine-containing regimen

Highlights

  1. 1
    Annals of oncology : official journal of the European Society for Medical Oncology · 2021
    PMID: 33741442DOISenior author396 citations
  2. 2
    Investigational new drugs · 2021
    PMID: 34417914DOISenior author6 citations
  3. 3
    JMIR cancer · 2022
    PMID: 35323123PMCID: PMC8990342DOISenior author5 citations

Publications

54 publications
Completed grants (2)
  • Sub-PI
    Development of a Urine Test for the Early Detection of Liver Cancer
    National Cancer Institute · 2015–2016 · via JBS Sciences
    R44CA165312-03 EW
  • MPI
    PHASE II TRIAL OF FOLFOX6, BEVACIZUMAB AND CETUXIMAB IN PATIENTS
    NCRR · 2006–2007 · via NIH RePORTER
    M01RR000047-47

Clinical research

7 studies

Active

1 study
  • PI
    A Phase 1/2 Study of M3814 (Peposertib) in Combination With Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma
    PHASE1; PHASE2 · National Cancer Institute · OPEN TO ACCRUAL (as of 2024)
    Locally Advanced Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8
    NCT04172532
Completed & closed trials (6)
  • PI
    A Randomized, Open-Label, Phase II Trial of Nab-paclitaxel + Gemcitabine With or Without Botensilimab (AGEN1181) in Patients With Metastatic Pancreatic Cancer Who Have Progressed on Prior 5FU + Leucovorin + Irinotecan + Oxaliplatin (FOLFIRINOX)
    PHASE2 · Agenus Inc · IRB STUDY CLOSURE (as of 2026)
    Metastatic Pancreatic Ductal Adenocarcinoma
    NCT05630183
  • PI
    Compassionate Use of Botensilimab (AGEN1181) in Combination with nab-Paclitaxel and Gemcitabine for Treatment of Pancreatic Cancer in Patient L-T
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2025)
  • PI
    A Pragmatic Randomized Phase II Trial Evaluating Total Ablative Therapy for Patients With Limited Metastatic Colorectal Cancer: Evaluating Radiation, Ablation, and Surgery (ERASur)
    PHASE2 · Alliance for Clinical Trials in Oncology · CLOSED TO ACCRUAL (as of 2025)
    Metastatic Colorectal Adenocarcinoma; Stage IV Colorectal Cancer AJCC v8; Oligometastatic Colorectal Carcinoma
    NCT05673148
  • PI
    Compassionate Use of Botensilimab (AGEN1181) in Combination with nab-Paclitaxel and Gemcitabine for Treatment of Pancreatic Cancer in Patient C-H
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2024)
  • PI
    Single-Patient IDE for Use of NovoTTF-200T Device in Patient N-S
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2024)
  • PI
    Single-Patient IDE for Use of NovoTTF-200T Device in Patient S-B
    Weill Medical College of Cornell University · IRB STUDY CLOSURE (as of 2024)

External relationships

Leadership Roles

American Jewish Medical Association · Novocure, Inc. · Oceans of Blessings · The Jack and Jill Late Stage Cancer Foundation · The POLG Foundation

Ownership

Let's Win Pancreatic Cancer · Novocure, Inc.

Advisory/Scientific Board Member

FORCE-Facing Our Risk of Cancer Empowered INC · Let's Win Pancreatic Cancer · Revolution Medicines, Inc. · Stephenson Global Pancreatic Cancer Research Institute

Other

Natera, Inc.